A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission
Excitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) tha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/12190 |
| _version_ | 1811201053963583488 |
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| author | Gilles Ouanounou Gérard Baux Thierry Bal |
| author_facet | Gilles Ouanounou Gérard Baux Thierry Bal |
| author_sort | Gilles Ouanounou |
| collection | DOAJ |
| description | Excitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) that the skeletal muscle cell constantly senses, through two identified calcium signals, synaptic events and their efficacy in eliciting spikes. These sensors trigger retrograde signal(s) that control presynaptic neurotransmitter release, resulting in synaptic potentiation or depression. In the absence of spikes, synaptic events trigger potentiation. Once the synapse is sufficiently strong to initiate spiking, the occurrence of these spikes activates a negative retrograde feedback. These opposing signals dynamically balance the synapse in order to continuously adjust neurotransmitter release to a level matching current muscle cell excitability. |
| first_indexed | 2024-04-12T02:14:24Z |
| format | Article |
| id | doaj.art-3c9346d446bc41b5a40f5411d7dae445 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:14:24Z |
| publishDate | 2016-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3c9346d446bc41b5a40f5411d7dae4452022-12-22T03:52:17ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.12190A novel synaptic plasticity rule explains homeostasis of neuromuscular transmissionGilles Ouanounou0https://orcid.org/0000-0001-5658-7005Gérard Baux1Thierry Bal2Unité de Neuroscience Information et Complexité, Centre National de la Recherche Scientifique, FRE 3693, Gif-sur-Yvette, FranceUnité de Neuroscience Information et Complexité, Centre National de la Recherche Scientifique, FRE 3693, Gif-sur-Yvette, FranceUnité de Neuroscience Information et Complexité, Centre National de la Recherche Scientifique, FRE 3693, Gif-sur-Yvette, FranceExcitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) that the skeletal muscle cell constantly senses, through two identified calcium signals, synaptic events and their efficacy in eliciting spikes. These sensors trigger retrograde signal(s) that control presynaptic neurotransmitter release, resulting in synaptic potentiation or depression. In the absence of spikes, synaptic events trigger potentiation. Once the synapse is sufficiently strong to initiate spiking, the occurrence of these spikes activates a negative retrograde feedback. These opposing signals dynamically balance the synapse in order to continuously adjust neurotransmitter release to a level matching current muscle cell excitability.https://elifesciences.org/articles/12190calcium signalingneuromuscular junctionhomeostatic plasticity |
| spellingShingle | Gilles Ouanounou Gérard Baux Thierry Bal A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission eLife calcium signaling neuromuscular junction homeostatic plasticity |
| title | A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| title_full | A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| title_fullStr | A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| title_full_unstemmed | A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| title_short | A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| title_sort | novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |
| topic | calcium signaling neuromuscular junction homeostatic plasticity |
| url | https://elifesciences.org/articles/12190 |
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