The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study
Yuling Xing,1,2 Tiantian Cheng,1,3 Fei Zhou,1,2 Huijuan Ma1,4,5 1Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People’s Republic of China; 2Graduate School of Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China; 3Department of Internal Medicine, Sc...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/the-association-between-vitamin-d-and-type-2-diabetes-mellitus-complic-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1811174200129355776 |
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| author | Xing Y Cheng T Zhou F Ma H |
| author_facet | Xing Y Cheng T Zhou F Ma H |
| author_sort | Xing Y |
| collection | DOAJ |
| description | Yuling Xing,1,2 Tiantian Cheng,1,3 Fei Zhou,1,2 Huijuan Ma1,4,5 1Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People’s Republic of China; 2Graduate School of Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China; 3Department of Internal Medicine, School of Clinical Medicine, North China University of Science and Technology, Tangshan, 063210, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, Hebei, 050051, People’s Republic of China; 5Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of ChinaCorrespondence: Huijuan Ma, Email huijuanma19@163.comObjective: To investigate the association between vitamin D deficiency and NAFLD risk in patients with type 2 diabetes mellitus (T2DM).Methods: Overall, 434 patients with T2DM admitted to Hebei General Hospital from January 2019 to December 2019 were selected as the study subjects. According to abdominal ultrasound findings, patients were divided into the NAFLD group and the non-NAFLD group. Participants were divided into two study groups according to the 25-hydroxyvitamin D [25(OH)D] level. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were < 20 ng/mL. Chi-square test and one-way analysis of variance were used to compare groups. The relationship between 25(OH)D and NAFLD risk was analyzed using correlation and regression analyses. Furthermore, subgroup analyses were performed to verify the robustness of the results.Results: The 25(OH)D level in patients with T2DM complicated by NAFLD was significantly lower than in patients with T2DM only. Vitamin D deficiency was highly prevalent among T2DM patients with NAFLD. This study suggested that vitamin D deficiency was an independent factor for developing NAFLD in patients with T2DM. T2DM patients with vitamin D deficiency had 2.045 times higher risk of developing NAFLD than those without vitamin D deficiency. Vitamin D deficiency was associated with high NAFLD preference in T2DM patients with BMI > 23kg/m2, but not those with BMI ≤ 23kg/m2. The significant correlation between vitamin D deficiency and NAFLD was found in participants with BMI > 23kg/m2, age ≤ 65 years, without hypertension, TG < 1.7mmol/l, HDL ≥ 1 mmol/l in men, ≥ 1.3 mmol/l in women, HBA1C ≤ 7%, or females.Conclusion: This study suggests that T2DM people with BMI > 23kg/m2 were more susceptible to NAFLD by vitamin D deficiency and that it is necessary to maintain optimal serum vitamin D levels in this population.Keywords: type 2 diabetes mellitus, non-alcoholic fatty liver disease, vitamin D |
| first_indexed | 2024-04-10T18:00:23Z |
| format | Article |
| id | doaj.art-3c9447c3b8d1405997979143820541f6 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:00:23Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-3c9447c3b8d1405997979143820541f62023-02-02T16:05:03ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-02-01Volume 1526928072621The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional StudyXing YCheng TZhou FMa HYuling Xing,1,2 Tiantian Cheng,1,3 Fei Zhou,1,2 Huijuan Ma1,4,5 1Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People’s Republic of China; 2Graduate School of Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China; 3Department of Internal Medicine, School of Clinical Medicine, North China University of Science and Technology, Tangshan, 063210, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, Hebei, 050051, People’s Republic of China; 5Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of ChinaCorrespondence: Huijuan Ma, Email huijuanma19@163.comObjective: To investigate the association between vitamin D deficiency and NAFLD risk in patients with type 2 diabetes mellitus (T2DM).Methods: Overall, 434 patients with T2DM admitted to Hebei General Hospital from January 2019 to December 2019 were selected as the study subjects. According to abdominal ultrasound findings, patients were divided into the NAFLD group and the non-NAFLD group. Participants were divided into two study groups according to the 25-hydroxyvitamin D [25(OH)D] level. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were < 20 ng/mL. Chi-square test and one-way analysis of variance were used to compare groups. The relationship between 25(OH)D and NAFLD risk was analyzed using correlation and regression analyses. Furthermore, subgroup analyses were performed to verify the robustness of the results.Results: The 25(OH)D level in patients with T2DM complicated by NAFLD was significantly lower than in patients with T2DM only. Vitamin D deficiency was highly prevalent among T2DM patients with NAFLD. This study suggested that vitamin D deficiency was an independent factor for developing NAFLD in patients with T2DM. T2DM patients with vitamin D deficiency had 2.045 times higher risk of developing NAFLD than those without vitamin D deficiency. Vitamin D deficiency was associated with high NAFLD preference in T2DM patients with BMI > 23kg/m2, but not those with BMI ≤ 23kg/m2. The significant correlation between vitamin D deficiency and NAFLD was found in participants with BMI > 23kg/m2, age ≤ 65 years, without hypertension, TG < 1.7mmol/l, HDL ≥ 1 mmol/l in men, ≥ 1.3 mmol/l in women, HBA1C ≤ 7%, or females.Conclusion: This study suggests that T2DM people with BMI > 23kg/m2 were more susceptible to NAFLD by vitamin D deficiency and that it is necessary to maintain optimal serum vitamin D levels in this population.Keywords: type 2 diabetes mellitus, non-alcoholic fatty liver disease, vitamin Dhttps://www.dovepress.com/the-association-between-vitamin-d-and-type-2-diabetes-mellitus-complic-peer-reviewed-fulltext-article-DMSOtype 2 diabetes mellitusnon-alcoholic fatty liver disease;vitamin d |
| spellingShingle | Xing Y Cheng T Zhou F Ma H The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study Diabetes, Metabolic Syndrome and Obesity type 2 diabetes mellitus non-alcoholic fatty liver disease;vitamin d |
| title | The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study |
| title_full | The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study |
| title_fullStr | The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study |
| title_full_unstemmed | The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study |
| title_short | The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study |
| title_sort | association between vitamin d and type 2 diabetes mellitus complicated with non alcoholic fatty liver disease an observational cross sectional study |
| topic | type 2 diabetes mellitus non-alcoholic fatty liver disease;vitamin d |
| url | https://www.dovepress.com/the-association-between-vitamin-d-and-type-2-diabetes-mellitus-complic-peer-reviewed-fulltext-article-DMSO |
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