Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentity

Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentity

IntroductionFor pre-clinical drug development and precision oncology research, robust cancer cell models are essential. Patient-derived models in low passages retain more genetic and phenotypic characteristics of their original tumors than conventional cancer cell lines. Subentity, individual geneti...

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Bibliographic Details
Main Authors: Ingo Andus, Friedrich Prall, Michael Linnebacher, Christina S. Linnebacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
patient-derived cell lines (PDC)
lung tumors
non-small cell lung cancer (NSCLC)
in vitro therapy response
patient-individual tumor models
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1089681/full

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