Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults
Past research using hepatic rat microsomes showed that soy protein suppressed delta-6 desaturase activity (D6D) compared to casein (a dairy protein). The effects of soy and dairy on desaturase pathway activity in humans remain poorly investigated. The objective of this analysis was to investigate th...
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2817 |
| _version_ | 1797522486206660608 |
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| author | Melissa Gonzalez-Soto Salma A Abdelmagid David W.L. Ma Ahmed El-Sohemy David M Mutch |
| author_facet | Melissa Gonzalez-Soto Salma A Abdelmagid David W.L. Ma Ahmed El-Sohemy David M Mutch |
| author_sort | Melissa Gonzalez-Soto |
| collection | DOAJ |
| description | Past research using hepatic rat microsomes showed that soy protein suppressed delta-6 desaturase activity (D6D) compared to casein (a dairy protein). The effects of soy and dairy on desaturase pathway activity in humans remain poorly investigated. The objective of this analysis was to investigate the association between soy and dairy consumption with plasma fatty acids and estimate the desaturase pathway activity in a multiethnic Canadian population of young adults. We analyzed data from men (<i>n</i> = 319) and women (<i>n</i> = 764) previously collected for the Toronto Nutrigenomics and Health Study. Food frequency questionnaires and plasma fatty acids were assessed. Relationships between soy and dairy beverages and food consumption with estimated desaturase activities were assessed by regression models and by grouping participants according to beverage and food intake data. Weak inverse associations (<i>p</i> ≤ 0.05) were found between soy consumption and the overall desaturation pathway activity, specifically D6D activity. When participants were grouped based on soy and dairy consumption habits, omega-6 LC-PUFAs, as well as various estimates of the desaturase pathway activity, were significantly lower in individuals consuming soy (with or without dairy) compared to individuals consuming only fluid milk and dairy products. In conclusion, soy consumption, not dairy consumption, appears to suppress desaturase pathway activity. |
| first_indexed | 2024-03-10T08:30:04Z |
| format | Article |
| id | doaj.art-3c96794cc0dd49e3911972eb8fa1f4b9 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:30:04Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3c96794cc0dd49e3911972eb8fa1f4b92023-11-22T09:06:34ZengMDPI AGNutrients2072-66432021-08-01138281710.3390/nu13082817Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young AdultsMelissa Gonzalez-Soto0Salma A Abdelmagid1David W.L. Ma2Ahmed El-Sohemy3David M Mutch4Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A8, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaPast research using hepatic rat microsomes showed that soy protein suppressed delta-6 desaturase activity (D6D) compared to casein (a dairy protein). The effects of soy and dairy on desaturase pathway activity in humans remain poorly investigated. The objective of this analysis was to investigate the association between soy and dairy consumption with plasma fatty acids and estimate the desaturase pathway activity in a multiethnic Canadian population of young adults. We analyzed data from men (<i>n</i> = 319) and women (<i>n</i> = 764) previously collected for the Toronto Nutrigenomics and Health Study. Food frequency questionnaires and plasma fatty acids were assessed. Relationships between soy and dairy beverages and food consumption with estimated desaturase activities were assessed by regression models and by grouping participants according to beverage and food intake data. Weak inverse associations (<i>p</i> ≤ 0.05) were found between soy consumption and the overall desaturation pathway activity, specifically D6D activity. When participants were grouped based on soy and dairy consumption habits, omega-6 LC-PUFAs, as well as various estimates of the desaturase pathway activity, were significantly lower in individuals consuming soy (with or without dairy) compared to individuals consuming only fluid milk and dairy products. In conclusion, soy consumption, not dairy consumption, appears to suppress desaturase pathway activity.https://www.mdpi.com/2072-6643/13/8/2817humansfluid milkdairysoy beverageplant-based beverageLC-PUFA |
| spellingShingle | Melissa Gonzalez-Soto Salma A Abdelmagid David W.L. Ma Ahmed El-Sohemy David M Mutch Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults Nutrients humans fluid milk dairy soy beverage plant-based beverage LC-PUFA |
| title | Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults |
| title_full | Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults |
| title_fullStr | Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults |
| title_full_unstemmed | Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults |
| title_short | Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults |
| title_sort | soy consumption but not dairy consumption is inversely associated with fatty acid desaturase activity in young adults |
| topic | humans fluid milk dairy soy beverage plant-based beverage LC-PUFA |
| url | https://www.mdpi.com/2072-6643/13/8/2817 |
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