Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model
Abstract Alzheimer's disease is the most common neurodegenerative disorder, with cognitive as well as behavioral manifestations. Also related to this pathology, is the decreased production and activation of some neurotransmitters, such as Serotonin, which is derived from the Tryptophan. Differe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2021-12-01
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| Series: | Brazilian Archives of Biology and Technology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000200228&tlng=en |
| _version_ | 1798014962279383040 |
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| author | Meirielly Furmann Andressa Leticia Miri Andressa Panegalli Hosni Ivo Ilvan Kerppers Aristides Machado-Rodrigues Luis Paulo Gomes Mascarenhas |
| author_facet | Meirielly Furmann Andressa Leticia Miri Andressa Panegalli Hosni Ivo Ilvan Kerppers Aristides Machado-Rodrigues Luis Paulo Gomes Mascarenhas |
| author_sort | Meirielly Furmann |
| collection | DOAJ |
| description | Abstract Alzheimer's disease is the most common neurodegenerative disorder, with cognitive as well as behavioral manifestations. Also related to this pathology, is the decreased production and activation of some neurotransmitters, such as Serotonin, which is derived from the Tryptophan. Different methods to improve the effect and performance of some drugs have been studied including the Nanoparticles. The objective was to analyze the efficacy of L-tryptophan and L-tryptophan Nanoparticles in the acute response of motor and cognitive behavior in an Alzheimer's experimental model. Methods: 15 Wistar rats, divided into 3 groups (n = 5): GC (Alzheimer's control group), GLt (L-tryptophan), and GN (Nanoparticles). They were treated for six consecutive days. Anxiety tests, spatial memory tests, aversive memory tests, and motor behavior tests were all performed during this study. In the analysis of anxiety, improvement was observed in both treatments, being that GN presented improvement in two variables: freezing (79±18.8; 74.6±14.2) and TBF (287.8±1.08; 268±40.8). GLt only presented improvement in freezing (103.8±44.4). In the spatial memory analysis, there were no significant differences in aversive memory and motor behavior during the treatments. During the Size Effect analysis treatments, it is possible to observe some differences both in anxiety and motor behavior, precisely where NG presented better results than GLt. Even in a short period of time, the nanoparticles demonstrated great benefits as a treatment method. Conclusion: the use of nanoparticles is an effective treatment against changes in motor and cognitive behavior caused by Alzheimer´s, as it lowers anxiety and improves motor behavior. |
| first_indexed | 2024-04-11T15:26:36Z |
| format | Article |
| id | doaj.art-3c96c6150f1a4584a7cf6dcc7f08d9ac |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-04-11T15:26:36Z |
| publishDate | 2021-12-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-3c96c6150f1a4584a7cf6dcc7f08d9ac2022-12-22T04:16:14ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242021-12-0164spe10.1590/1678-4324-75years-2021210408Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental ModelMeirielly Furmannhttps://orcid.org/0000-0002-8045-5755Andressa Leticia Mirihttps://orcid.org/0000-0002-9057-5339Andressa Panegalli Hosnihttps://orcid.org/0000-0002-2980-9773Ivo Ilvan Kerppershttps://orcid.org/0000-0001-5745-2006Aristides Machado-Rodrigueshttps://orcid.org/0000-0002-7169-8034Luis Paulo Gomes Mascarenhashttps://orcid.org/0000-0002-7762-2727Abstract Alzheimer's disease is the most common neurodegenerative disorder, with cognitive as well as behavioral manifestations. Also related to this pathology, is the decreased production and activation of some neurotransmitters, such as Serotonin, which is derived from the Tryptophan. Different methods to improve the effect and performance of some drugs have been studied including the Nanoparticles. The objective was to analyze the efficacy of L-tryptophan and L-tryptophan Nanoparticles in the acute response of motor and cognitive behavior in an Alzheimer's experimental model. Methods: 15 Wistar rats, divided into 3 groups (n = 5): GC (Alzheimer's control group), GLt (L-tryptophan), and GN (Nanoparticles). They were treated for six consecutive days. Anxiety tests, spatial memory tests, aversive memory tests, and motor behavior tests were all performed during this study. In the analysis of anxiety, improvement was observed in both treatments, being that GN presented improvement in two variables: freezing (79±18.8; 74.6±14.2) and TBF (287.8±1.08; 268±40.8). GLt only presented improvement in freezing (103.8±44.4). In the spatial memory analysis, there were no significant differences in aversive memory and motor behavior during the treatments. During the Size Effect analysis treatments, it is possible to observe some differences both in anxiety and motor behavior, precisely where NG presented better results than GLt. Even in a short period of time, the nanoparticles demonstrated great benefits as a treatment method. Conclusion: the use of nanoparticles is an effective treatment against changes in motor and cognitive behavior caused by Alzheimer´s, as it lowers anxiety and improves motor behavior.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000200228&tlng=enAlzheimer's diseasenanoparticlestryptophan |
| spellingShingle | Meirielly Furmann Andressa Leticia Miri Andressa Panegalli Hosni Ivo Ilvan Kerppers Aristides Machado-Rodrigues Luis Paulo Gomes Mascarenhas Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model Brazilian Archives of Biology and Technology Alzheimer's disease nanoparticles tryptophan |
| title | Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model |
| title_full | Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model |
| title_fullStr | Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model |
| title_full_unstemmed | Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model |
| title_short | Comparative Study of the Efficacy of L-Tryptophan Nanoparticles on Motor and Cognitive Behavior in an Alzheimer's Experimental Model |
| title_sort | comparative study of the efficacy of l tryptophan nanoparticles on motor and cognitive behavior in an alzheimer s experimental model |
| topic | Alzheimer's disease nanoparticles tryptophan |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000200228&tlng=en |
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