Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells
As the common pathological basis of various cardiovascular diseases, the morbidity and mortality of atherosclerosis (AS) have increased in recent years. Unfortunately, there are still many problems in the treatment of AS, and the prevention and treatment of the disease is not ideal. Up to now, the o...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1141180/full |
| _version_ | 1797895469153648640 |
|---|---|
| author | Ruo-Lan Li Ling-Yu Wang Hu-Xinyue Duan Die Qian Qing Zhang Li-Sha He Xue-Ping Li |
| author_facet | Ruo-Lan Li Ling-Yu Wang Hu-Xinyue Duan Die Qian Qing Zhang Li-Sha He Xue-Ping Li |
| author_sort | Ruo-Lan Li |
| collection | DOAJ |
| description | As the common pathological basis of various cardiovascular diseases, the morbidity and mortality of atherosclerosis (AS) have increased in recent years. Unfortunately, there are still many problems in the treatment of AS, and the prevention and treatment of the disease is not ideal. Up to now, the occurrence and development of AS can roughly include endothelial cell dysfunction, vascular smooth muscle cell proliferation, inflammation, foam cell production, and neoangiogenesis. Among them, endothelial dysfunction, as an early event of AS, plays a particularly important role in promoting the development of AS. In addition, oxidative stress occurs throughout the causes of endothelial dysfunction. Some previous studies have shown that flavonoids derived from herbal medicines are typical secondary metabolites. Due to its structural presence of multiple active hydroxyl groups, it is able to exert antioxidant activity in diseases. Therefore, in this review, we will search PubMed, Web of Science, Elesvier, Wliey, Springer for relevant literature, focusing on flavonoids extracted from herbal medicines, and summarizing how they can prevent endothelial dysfunction by inhibiting oxidative stress. Meanwhile, in our study, we found that flavonoid represented by quercetin and naringenin showed superior protective effects both in vivo and in vitro, suggesting the potential of flavonoid compounds in the treatment of AS. |
| first_indexed | 2024-04-10T07:27:21Z |
| format | Article |
| id | doaj.art-3c990a9e30a8498386cce9553ffedd8f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T07:27:21Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3c990a9e30a8498386cce9553ffedd8f2023-02-24T04:51:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.11411801141180Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cellsRuo-Lan Li0Ling-Yu Wang1Hu-Xinyue Duan2Die Qian3Qing Zhang4Li-Sha He5Xue-Ping Li6Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAs the common pathological basis of various cardiovascular diseases, the morbidity and mortality of atherosclerosis (AS) have increased in recent years. Unfortunately, there are still many problems in the treatment of AS, and the prevention and treatment of the disease is not ideal. Up to now, the occurrence and development of AS can roughly include endothelial cell dysfunction, vascular smooth muscle cell proliferation, inflammation, foam cell production, and neoangiogenesis. Among them, endothelial dysfunction, as an early event of AS, plays a particularly important role in promoting the development of AS. In addition, oxidative stress occurs throughout the causes of endothelial dysfunction. Some previous studies have shown that flavonoids derived from herbal medicines are typical secondary metabolites. Due to its structural presence of multiple active hydroxyl groups, it is able to exert antioxidant activity in diseases. Therefore, in this review, we will search PubMed, Web of Science, Elesvier, Wliey, Springer for relevant literature, focusing on flavonoids extracted from herbal medicines, and summarizing how they can prevent endothelial dysfunction by inhibiting oxidative stress. Meanwhile, in our study, we found that flavonoid represented by quercetin and naringenin showed superior protective effects both in vivo and in vitro, suggesting the potential of flavonoid compounds in the treatment of AS.https://www.frontiersin.org/articles/10.3389/fphar.2023.1141180/fullatherosclerosisendothelial dysfunctionoxidative stressherbal medicinesflavonoids |
| spellingShingle | Ruo-Lan Li Ling-Yu Wang Hu-Xinyue Duan Die Qian Qing Zhang Li-Sha He Xue-Ping Li Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells Frontiers in Pharmacology atherosclerosis endothelial dysfunction oxidative stress herbal medicines flavonoids |
| title | Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells |
| title_full | Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells |
| title_fullStr | Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells |
| title_full_unstemmed | Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells |
| title_short | Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells |
| title_sort | natural flavonoids derived from herbal medicines are potential anti atherogenic agents by inhibiting oxidative stress in endothelial cells |
| topic | atherosclerosis endothelial dysfunction oxidative stress herbal medicines flavonoids |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1141180/full |
| work_keys_str_mv | AT ruolanli naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT lingyuwang naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT huxinyueduan naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT dieqian naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT qingzhang naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT lishahe naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells AT xuepingli naturalflavonoidsderivedfromherbalmedicinesarepotentialantiatherogenicagentsbyinhibitingoxidativestressinendothelialcells |