Obesity-Induced Changes in Bone Marrow Homeostasis
Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. O...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00294/full |
| _version_ | 1819101945455968256 |
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| author | Andrea Benova Michaela Tencerova |
| author_facet | Andrea Benova Michaela Tencerova |
| author_sort | Andrea Benova |
| collection | DOAJ |
| description | Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism. |
| first_indexed | 2024-12-22T01:26:44Z |
| format | Article |
| id | doaj.art-3c9ac3298062423a9842eebee04023a7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T01:26:44Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3c9ac3298062423a9842eebee04023a72022-12-21T18:43:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-05-011110.3389/fendo.2020.00294526531Obesity-Induced Changes in Bone Marrow HomeostasisAndrea BenovaMichaela TencerovaObesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism.https://www.frontiersin.org/article/10.3389/fendo.2020.00294/fullbone marrow microenvironmentbone marrow mesenchymal stem cellshematopoietic stem cellsimmune responsesobesitylife-style interventions |
| spellingShingle | Andrea Benova Michaela Tencerova Obesity-Induced Changes in Bone Marrow Homeostasis Frontiers in Endocrinology bone marrow microenvironment bone marrow mesenchymal stem cells hematopoietic stem cells immune responses obesity life-style interventions |
| title | Obesity-Induced Changes in Bone Marrow Homeostasis |
| title_full | Obesity-Induced Changes in Bone Marrow Homeostasis |
| title_fullStr | Obesity-Induced Changes in Bone Marrow Homeostasis |
| title_full_unstemmed | Obesity-Induced Changes in Bone Marrow Homeostasis |
| title_short | Obesity-Induced Changes in Bone Marrow Homeostasis |
| title_sort | obesity induced changes in bone marrow homeostasis |
| topic | bone marrow microenvironment bone marrow mesenchymal stem cells hematopoietic stem cells immune responses obesity life-style interventions |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00294/full |
| work_keys_str_mv | AT andreabenova obesityinducedchangesinbonemarrowhomeostasis AT michaelatencerova obesityinducedchangesinbonemarrowhomeostasis |