Validation of population-based disease simulation models: a review of concepts and methods

<p>Abstract</p> <p>Background</p> <p>Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of populatio...

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Main Authors: Sharif Behnam, Harper Samuel, Abrahamowicz Michal, Oderkirk Jillian, Flanagan William M, Buckeridge David L, Manuel Douglas G, Finès Philippe, Kopec Jacek A, Okhmatovskaia Anya, Sayre Eric C, Rahman M Mushfiqur, Wolfson Michael C
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Public Health
Online Access:http://www.biomedcentral.com/1471-2458/10/710
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author Sharif Behnam
Harper Samuel
Abrahamowicz Michal
Oderkirk Jillian
Flanagan William M
Buckeridge David L
Manuel Douglas G
Finès Philippe
Kopec Jacek A
Okhmatovskaia Anya
Sayre Eric C
Rahman M Mushfiqur
Wolfson Michael C
author_facet Sharif Behnam
Harper Samuel
Abrahamowicz Michal
Oderkirk Jillian
Flanagan William M
Buckeridge David L
Manuel Douglas G
Finès Philippe
Kopec Jacek A
Okhmatovskaia Anya
Sayre Eric C
Rahman M Mushfiqur
Wolfson Michael C
author_sort Sharif Behnam
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of population-based disease simulation models.</p> <p>Methods</p> <p>We developed a comprehensive framework for validating population-based chronic disease simulation models and used this framework in a review of published model validation guidelines. Based on the review, we formulated a set of recommendations for gathering evidence of model credibility.</p> <p>Results</p> <p>Evidence of model credibility derives from examining: 1) the process of model development, 2) the performance of a model, and 3) the quality of decisions based on the model. Many important issues in model validation are insufficiently addressed by current guidelines. These issues include a detailed evaluation of different data sources, graphical representation of models, computer programming, model calibration, between-model comparisons, sensitivity analysis, and predictive validity. The role of external data in model validation depends on the purpose of the model (e.g., decision analysis versus prediction). More research is needed on the methods of comparing the quality of decisions based on different models.</p> <p>Conclusion</p> <p>As the role of simulation modeling in population health is increasing and models are becoming more complex, there is a need for further improvements in model validation methodology and common standards for evaluating model credibility.</p>
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spelling doaj.art-3c9adc3c76a5421b83e82b988cd0a7cc2022-12-22T03:08:34ZengBMCBMC Public Health1471-24582010-11-0110171010.1186/1471-2458-10-710Validation of population-based disease simulation models: a review of concepts and methodsSharif BehnamHarper SamuelAbrahamowicz MichalOderkirk JillianFlanagan William MBuckeridge David LManuel Douglas GFinès PhilippeKopec Jacek AOkhmatovskaia AnyaSayre Eric CRahman M MushfiqurWolfson Michael C<p>Abstract</p> <p>Background</p> <p>Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of population-based disease simulation models.</p> <p>Methods</p> <p>We developed a comprehensive framework for validating population-based chronic disease simulation models and used this framework in a review of published model validation guidelines. Based on the review, we formulated a set of recommendations for gathering evidence of model credibility.</p> <p>Results</p> <p>Evidence of model credibility derives from examining: 1) the process of model development, 2) the performance of a model, and 3) the quality of decisions based on the model. Many important issues in model validation are insufficiently addressed by current guidelines. These issues include a detailed evaluation of different data sources, graphical representation of models, computer programming, model calibration, between-model comparisons, sensitivity analysis, and predictive validity. The role of external data in model validation depends on the purpose of the model (e.g., decision analysis versus prediction). More research is needed on the methods of comparing the quality of decisions based on different models.</p> <p>Conclusion</p> <p>As the role of simulation modeling in population health is increasing and models are becoming more complex, there is a need for further improvements in model validation methodology and common standards for evaluating model credibility.</p>http://www.biomedcentral.com/1471-2458/10/710
spellingShingle Sharif Behnam
Harper Samuel
Abrahamowicz Michal
Oderkirk Jillian
Flanagan William M
Buckeridge David L
Manuel Douglas G
Finès Philippe
Kopec Jacek A
Okhmatovskaia Anya
Sayre Eric C
Rahman M Mushfiqur
Wolfson Michael C
Validation of population-based disease simulation models: a review of concepts and methods
BMC Public Health
title Validation of population-based disease simulation models: a review of concepts and methods
title_full Validation of population-based disease simulation models: a review of concepts and methods
title_fullStr Validation of population-based disease simulation models: a review of concepts and methods
title_full_unstemmed Validation of population-based disease simulation models: a review of concepts and methods
title_short Validation of population-based disease simulation models: a review of concepts and methods
title_sort validation of population based disease simulation models a review of concepts and methods
url http://www.biomedcentral.com/1471-2458/10/710
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