Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

Ataxia Telangiectasia (AT) is a rare inherited disorder characterized by progressive cerebellar ataxia, chromosomal instability, cancer susceptibility and immunodeficiency. AT is caused by mutations in the ATM gene, which is involved in multiple processes linked to DNA double strand break repair. Im...

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Bibliographic Details
Main Authors: Thomas J. Weitering, Janine E. Melsen, Monique M. van Ostaijen-ten Dam, Corry M. R. Weemaes, Marco W. Schilham, Mirjam van der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Ataxia Telangiectasia
cellular immunity
stem cell memory T cells
spectral flow cytometry
recent thymic emigrants
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.686333/full

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