Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells
Melanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products t...
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MDPI AG
2022-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/2/123 |
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| author | Jun-Geon Je Yunfei Jiang Jun-Ho Heo Xining Li You-Jin Jeon Bo-Mi Ryu |
| author_facet | Jun-Geon Je Yunfei Jiang Jun-Ho Heo Xining Li You-Jin Jeon Bo-Mi Ryu |
| author_sort | Jun-Geon Je |
| collection | DOAJ |
| description | Melanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products that inhibit and control tyrosinase activity, most studies have not been extended to in vivo applications. Phlorofucofuroeckol-A (PFF-A, 12.5–100 µM) isolated from <i>Ecklonia cava</i> has previously been shown to have tyrosinase-mitigative effects in B16F10 cells, but it has not been evaluated in an in vivo model, and its underlying mechanism for anti-melanogenic effects has not been studied. In the present study, we evaluated the safety and efficacy of PFF-A for anti-melanogenic effects in an in vivo model. We selected low doses of PFF-A (1.5–15 nM) and investigated their mitigative effects on pigmentation stimulated by α-MSH in vivo and their related-mechanism in an in vitro model. The findings suggest that low-dose PFF-A derived from <i>E. cava</i> suppresses pigmentation in vivo and melanogenesis in vitro. Therefore, this study presents the possibility that PFF-A could be utilized as a new anti-melanogenic agent in the cosmeceutical industries. |
| first_indexed | 2024-03-09T21:33:11Z |
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| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T21:33:11Z |
| publishDate | 2022-02-01 |
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| series | Marine Drugs |
| spelling | doaj.art-3c9ea07ce1f54085b89d23940873f38f2023-11-23T20:50:13ZengMDPI AGMarine Drugs1660-33972022-02-0120212310.3390/md20020123Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 CellsJun-Geon Je0Yunfei Jiang1Jun-Ho Heo2Xining Li3You-Jin Jeon4Bo-Mi Ryu5Department of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaSchool of Food Engineering, Jilin Agriculture Science and Technology University, Jilin 132101, ChinaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaSchool of Life Sciences, Northeast Normal University, Changchun 130024, ChinaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaMelanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products that inhibit and control tyrosinase activity, most studies have not been extended to in vivo applications. Phlorofucofuroeckol-A (PFF-A, 12.5–100 µM) isolated from <i>Ecklonia cava</i> has previously been shown to have tyrosinase-mitigative effects in B16F10 cells, but it has not been evaluated in an in vivo model, and its underlying mechanism for anti-melanogenic effects has not been studied. In the present study, we evaluated the safety and efficacy of PFF-A for anti-melanogenic effects in an in vivo model. We selected low doses of PFF-A (1.5–15 nM) and investigated their mitigative effects on pigmentation stimulated by α-MSH in vivo and their related-mechanism in an in vitro model. The findings suggest that low-dose PFF-A derived from <i>E. cava</i> suppresses pigmentation in vivo and melanogenesis in vitro. Therefore, this study presents the possibility that PFF-A could be utilized as a new anti-melanogenic agent in the cosmeceutical industries.https://www.mdpi.com/1660-3397/20/2/123phlorofucofuroeckol-A<i>Ecklonia cava</i>melanogenesisB16F10 cell lineszebrafish |
| spellingShingle | Jun-Geon Je Yunfei Jiang Jun-Ho Heo Xining Li You-Jin Jeon Bo-Mi Ryu Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells Marine Drugs phlorofucofuroeckol-A <i>Ecklonia cava</i> melanogenesis B16F10 cell lines zebrafish |
| title | Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells |
| title_full | Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells |
| title_fullStr | Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells |
| title_full_unstemmed | Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells |
| title_short | Mitigative Effects of PFF-A Isolated from <i>Ecklonia cava</i> on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells |
| title_sort | mitigative effects of pff a isolated from i ecklonia cava i on pigmentation in a zebrafish model and melanogenesis in b16f10 cells |
| topic | phlorofucofuroeckol-A <i>Ecklonia cava</i> melanogenesis B16F10 cell lines zebrafish |
| url | https://www.mdpi.com/1660-3397/20/2/123 |
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