Drug delivery using nanoparticles for cancer stem-like cell targeting
The theory of cancer stem-like cell (or cancer stem cell, CSC) has been established to explain how tumor heterogeneity arises and contributes to tumor progression in diverse cancer types. CSCs are believed to drive tumor growth and elicit resistance to conventional therapeutics. Therefore, CSCs are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00084/full |
| _version_ | 1818050980827103232 |
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| author | Bing eLu Xiaojia eHuang Jingxin eMo Jingxin eMo Wei eZhao Wei eZhao |
| author_facet | Bing eLu Xiaojia eHuang Jingxin eMo Jingxin eMo Wei eZhao Wei eZhao |
| author_sort | Bing eLu |
| collection | DOAJ |
| description | The theory of cancer stem-like cell (or cancer stem cell, CSC) has been established to explain how tumor heterogeneity arises and contributes to tumor progression in diverse cancer types. CSCs are believed to drive tumor growth and elicit resistance to conventional therapeutics. Therefore, CSCs are becoming novel target in both medical researches and clinical studies. Emerging evidences showed that nanoparticles effectively inhibit many types of CSCs by targeting various specific markers (aldehyde dehydrogenases, CD44, CD90, and CD133) and signaling pathways (Notch, Hedgehog, and TGF-β), which are critically involved in CSC function and maintenance. In this review, we briefly summarize the current status of CSC research and review a number of state-of-the-art nanomedicine approaches targeting CSC. In addition, we discuss emerging therapeutic strategies using epigenetic drugs to eliminate CSCs and inhibit cancer cell reprogramming. |
| first_indexed | 2024-12-10T11:02:06Z |
| format | Article |
| id | doaj.art-3c9f6ca5447448a1a3df09d5a07ffb66 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T11:02:06Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3c9f6ca5447448a1a3df09d5a07ffb662022-12-22T01:51:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-04-01710.3389/fphar.2016.00084186585Drug delivery using nanoparticles for cancer stem-like cell targetingBing eLu0Xiaojia eHuang1Jingxin eMo2Jingxin eMo3Wei eZhao4Wei eZhao5Sun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversityThe theory of cancer stem-like cell (or cancer stem cell, CSC) has been established to explain how tumor heterogeneity arises and contributes to tumor progression in diverse cancer types. CSCs are believed to drive tumor growth and elicit resistance to conventional therapeutics. Therefore, CSCs are becoming novel target in both medical researches and clinical studies. Emerging evidences showed that nanoparticles effectively inhibit many types of CSCs by targeting various specific markers (aldehyde dehydrogenases, CD44, CD90, and CD133) and signaling pathways (Notch, Hedgehog, and TGF-β), which are critically involved in CSC function and maintenance. In this review, we briefly summarize the current status of CSC research and review a number of state-of-the-art nanomedicine approaches targeting CSC. In addition, we discuss emerging therapeutic strategies using epigenetic drugs to eliminate CSCs and inhibit cancer cell reprogramming.http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00084/fullInduced Pluripotent Stem Cellscombination therapynanoparticleepigenetic drugsCancer stem-like cell |
| spellingShingle | Bing eLu Xiaojia eHuang Jingxin eMo Jingxin eMo Wei eZhao Wei eZhao Drug delivery using nanoparticles for cancer stem-like cell targeting Frontiers in Pharmacology Induced Pluripotent Stem Cells combination therapy nanoparticle epigenetic drugs Cancer stem-like cell |
| title | Drug delivery using nanoparticles for cancer stem-like cell targeting |
| title_full | Drug delivery using nanoparticles for cancer stem-like cell targeting |
| title_fullStr | Drug delivery using nanoparticles for cancer stem-like cell targeting |
| title_full_unstemmed | Drug delivery using nanoparticles for cancer stem-like cell targeting |
| title_short | Drug delivery using nanoparticles for cancer stem-like cell targeting |
| title_sort | drug delivery using nanoparticles for cancer stem like cell targeting |
| topic | Induced Pluripotent Stem Cells combination therapy nanoparticle epigenetic drugs Cancer stem-like cell |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00084/full |
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