2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of <i>Plasmodium falciparum</i>: An In Silico Approach with Experimental Validation

2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of <i>Plasmodium falciparum</i>: An In Silico Approach with Experimental Validation

Malaria is an infectious disease caused by <i>Plasmodium</i> spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molecular similarity index analysis...

Full description

Bibliographic Details
Main Authors: Marcos Lorca, Gisela C. Muscia, Susana Pérez-Benavente, José M. Bautista, Alison Acosta, Cesar González, Gianfranco Sabadini, Jaime Mella, Silvia E. Asís, Marco Mellado
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Pharmaceuticals
Subjects:
malaria
drug design
2D- and 3D-QSAR models
quinoline synthesis
experimental validation
biocompatibility
Online Access:https://www.mdpi.com/1424-8247/17/7/889

Internet

https://www.mdpi.com/1424-8247/17/7/889

Similar Items