A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome
Organizing pneumonia (OP) is a lung pathology mainly affecting distal lung structures. Its etiology is often unknown, in which case it is termed cryptogenic organizing pneumonia (COP). Of those cases of OP with an identified cause, the usual culprits include infections, medications, and radiation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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McGill University
2023-05-01
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| Series: | McGill Journal of Medicine |
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| Online Access: | https://mjm.mcgill.ca/article/view/983 |
| _version_ | 1797685695869878272 |
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| author | Kelly Ann Hutchinson Carole-Ann Hébert Ajay Rajaram Pierre-Olivier Fiset Kevin Schwartzman |
| author_facet | Kelly Ann Hutchinson Carole-Ann Hébert Ajay Rajaram Pierre-Olivier Fiset Kevin Schwartzman |
| author_sort | Kelly Ann Hutchinson |
| collection | DOAJ |
| description |
Organizing pneumonia (OP) is a lung pathology mainly affecting distal lung structures. Its etiology is often unknown, in which case it is termed cryptogenic organizing pneumonia (COP). Of those cases of OP with an identified cause, the usual culprits include infections, medications, and radiation therapy. In this report, we present the case of a 73-year-old female on azacitidine –a pyrimidine analogue– used for treatment of myelodysplastic syndrome (MDS). The patient presented with fever, productive cough, and pleuritic chest pain. A CT of the chest, a bronchoalveolar lavage and a transthoracic biopsy were performed, and findings were consistent with OP, thought to be induced by azacitidine. The patient was treated with prednisone and subsequently showed significant improvement. Although rare, this case underlines the importance of considering OP in the context of non-resolving pulmonary infiltrates, particularly when there is a potentially relevant exposure, such as azacitidine.
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| first_indexed | 2024-03-12T00:49:01Z |
| format | Article |
| id | doaj.art-3ca164e387ef44698dadc53b11757bda |
| institution | Directory Open Access Journal |
| issn | 1201-026X 1715-8125 |
| language | English |
| last_indexed | 2024-03-12T00:49:01Z |
| publishDate | 2023-05-01 |
| publisher | McGill University |
| record_format | Article |
| series | McGill Journal of Medicine |
| spelling | doaj.art-3ca164e387ef44698dadc53b11757bda2023-09-14T15:27:31ZengMcGill UniversityMcGill Journal of Medicine1201-026X1715-81252023-05-0121110.26443/mjm.v21i1.983A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic SyndromeKelly Ann Hutchinson0Carole-Ann Hébert1Ajay Rajaram2Pierre-Olivier Fiset3Kevin Schwartzman4McGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityMcGill University Organizing pneumonia (OP) is a lung pathology mainly affecting distal lung structures. Its etiology is often unknown, in which case it is termed cryptogenic organizing pneumonia (COP). Of those cases of OP with an identified cause, the usual culprits include infections, medications, and radiation therapy. In this report, we present the case of a 73-year-old female on azacitidine –a pyrimidine analogue– used for treatment of myelodysplastic syndrome (MDS). The patient presented with fever, productive cough, and pleuritic chest pain. A CT of the chest, a bronchoalveolar lavage and a transthoracic biopsy were performed, and findings were consistent with OP, thought to be induced by azacitidine. The patient was treated with prednisone and subsequently showed significant improvement. Although rare, this case underlines the importance of considering OP in the context of non-resolving pulmonary infiltrates, particularly when there is a potentially relevant exposure, such as azacitidine. https://mjm.mcgill.ca/article/view/983organizing pneumonia, myelodysplastic syndrome, azacitidine |
| spellingShingle | Kelly Ann Hutchinson Carole-Ann Hébert Ajay Rajaram Pierre-Olivier Fiset Kevin Schwartzman A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome McGill Journal of Medicine organizing pneumonia, myelodysplastic syndrome, azacitidine |
| title | A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome |
| title_full | A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome |
| title_fullStr | A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome |
| title_full_unstemmed | A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome |
| title_short | A Case of Organizing Pneumonia Following Azacitidine Treatment for Myelodysplastic Syndrome |
| title_sort | case of organizing pneumonia following azacitidine treatment for myelodysplastic syndrome |
| topic | organizing pneumonia, myelodysplastic syndrome, azacitidine |
| url | https://mjm.mcgill.ca/article/view/983 |
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