ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2

ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2

KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscan<sup>TM</sup> screening platform, and we identified casein kinase 2 (CK2) as a novel t...

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Bibliographic Details
Main Authors: Nhu Nguyen Quynh Tran, Kwang-Hoon Chun
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
KD025
belumosudil
ROCK2
casein kinase
CK2
adipocyte differentiation
Online Access:https://www.mdpi.com/1420-3049/26/16/4747

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