Formins and membranes: anchoring cortical actin to the cell wall and beyond
Formins are evolutionarily conserved eukaryotic proteins participating in actin and microtubule organization. Land plants have three formin clades, with only two – Class I and II – present in angiosperms. Class I formins are often transmembrane proteins, residing at the plasmalemma and anchoring the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2013.00436/full |
| _version_ | 1819141880890261504 |
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| author | Fatima eCvrckova |
| author_facet | Fatima eCvrckova |
| author_sort | Fatima eCvrckova |
| collection | DOAJ |
| description | Formins are evolutionarily conserved eukaryotic proteins participating in actin and microtubule organization. Land plants have three formin clades, with only two – Class I and II – present in angiosperms. Class I formins are often transmembrane proteins, residing at the plasmalemma and anchoring the cortical cytoskeleton across the membrane to the cell wall, while Class II formins possess a PTEN-related membrane-binding domain. Lower plant Class III and non-plant formins usually contain domains predicted to bind RHO GTPases that are membrane-associated. Thus, some kind of membrane anchorage appears to be a common formin feature. Direct interactions between various non-plant formins and integral or peripheral membrane proteins have indeed been reported, with varying mechanisms and biological implications. Besides of summarizing new data on Class I and Class II formin-membrane relationships, this review surveys such non-classical formin-membrane interactions and examines which, if any, of them may be evolutionarily conserved and operating also in plants. FYVE, SH3 and BAR domain-containing proteins emerge as possible candidates for such conserved membrane-associated formin partners. |
| first_indexed | 2024-12-22T12:01:29Z |
| format | Article |
| id | doaj.art-3ca58a043ea1436fab4cf1226194f7d5 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-22T12:01:29Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-3ca58a043ea1436fab4cf1226194f7d52022-12-21T18:26:35ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2013-11-01410.3389/fpls.2013.0043669059Formins and membranes: anchoring cortical actin to the cell wall and beyondFatima eCvrckova0Charles University in Prague, Faculty of ScienceFormins are evolutionarily conserved eukaryotic proteins participating in actin and microtubule organization. Land plants have three formin clades, with only two – Class I and II – present in angiosperms. Class I formins are often transmembrane proteins, residing at the plasmalemma and anchoring the cortical cytoskeleton across the membrane to the cell wall, while Class II formins possess a PTEN-related membrane-binding domain. Lower plant Class III and non-plant formins usually contain domains predicted to bind RHO GTPases that are membrane-associated. Thus, some kind of membrane anchorage appears to be a common formin feature. Direct interactions between various non-plant formins and integral or peripheral membrane proteins have indeed been reported, with varying mechanisms and biological implications. Besides of summarizing new data on Class I and Class II formin-membrane relationships, this review surveys such non-classical formin-membrane interactions and examines which, if any, of them may be evolutionarily conserved and operating also in plants. FYVE, SH3 and BAR domain-containing proteins emerge as possible candidates for such conserved membrane-associated formin partners.http://journal.frontiersin.org/Journal/10.3389/fpls.2013.00436/fullCell PolarityEndocytosisActinforminvesicle traffickingplasmalemma |
| spellingShingle | Fatima eCvrckova Formins and membranes: anchoring cortical actin to the cell wall and beyond Frontiers in Plant Science Cell Polarity Endocytosis Actin formin vesicle trafficking plasmalemma |
| title | Formins and membranes: anchoring cortical actin to the cell wall and beyond |
| title_full | Formins and membranes: anchoring cortical actin to the cell wall and beyond |
| title_fullStr | Formins and membranes: anchoring cortical actin to the cell wall and beyond |
| title_full_unstemmed | Formins and membranes: anchoring cortical actin to the cell wall and beyond |
| title_short | Formins and membranes: anchoring cortical actin to the cell wall and beyond |
| title_sort | formins and membranes anchoring cortical actin to the cell wall and beyond |
| topic | Cell Polarity Endocytosis Actin formin vesicle trafficking plasmalemma |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2013.00436/full |
| work_keys_str_mv | AT fatimaecvrckova forminsandmembranesanchoringcorticalactintothecellwallandbeyond |