AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer
MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with othe...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322000936 |
| _version_ | 1818208608425345024 |
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| author | Pavan Kumar Kakumani |
| author_facet | Pavan Kumar Kakumani |
| author_sort | Pavan Kumar Kakumani |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with other RBPs to control mRNA metabolism. miRNA binding in 3′ untranslated regions (3′ UTRs) of mRNAs facilitates an intricate network of interactions between miRNA-AGO and RBPs, thus determining the fate of overlapping targets. Here, we review the current knowledge on the interplay between miRNA-AGO and multiple RBPs in different cellular contexts, the rules underlying their synergism and antagonism on target mRNAs, as well as highlight the implications of these regulatory modules in cancer initiation and progression. |
| first_indexed | 2024-12-12T04:47:31Z |
| format | Article |
| id | doaj.art-3ca59d3b785348008ff63c27f2bccaa7 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-12T04:47:31Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-3ca59d3b785348008ff63c27f2bccaa72022-12-22T00:37:35ZengElsevierTranslational Oncology1936-52332022-07-0121101434AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancerPavan Kumar Kakumani0Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, NL A1C 5S7, CanadaMicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with other RBPs to control mRNA metabolism. miRNA binding in 3′ untranslated regions (3′ UTRs) of mRNAs facilitates an intricate network of interactions between miRNA-AGO and RBPs, thus determining the fate of overlapping targets. Here, we review the current knowledge on the interplay between miRNA-AGO and multiple RBPs in different cellular contexts, the rules underlying their synergism and antagonism on target mRNAs, as well as highlight the implications of these regulatory modules in cancer initiation and progression.http://www.sciencedirect.com/science/article/pii/S1936523322000936miRNAsArgonaute proteinRBPsmRNAsmiRISCCancer |
| spellingShingle | Pavan Kumar Kakumani AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer Translational Oncology miRNAs Argonaute protein RBPs mRNAs miRISC Cancer |
| title | AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer |
| title_full | AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer |
| title_fullStr | AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer |
| title_full_unstemmed | AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer |
| title_short | AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer |
| title_sort | ago rbp crosstalk on target mrnas implications in mirna guided gene silencing and cancer |
| topic | miRNAs Argonaute protein RBPs mRNAs miRISC Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322000936 |
| work_keys_str_mv | AT pavankumarkakumani agorbpcrosstalkontargetmrnasimplicationsinmirnaguidedgenesilencingandcancer |