Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial
Mild traumatic brain injury (mTBI) can have lasting consequences on cognitive functioning and well-being. Goal-Oriented Attentional Self-Regulation (GOALS) training has been shown to improve attention and executive functioning, as well as emotional functioning, in veterans with chronic TBI. An ongoi...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2023-06-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0074 |
| _version_ | 1797346152618655744 |
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| author | Maria Kryza-Lacombe Rachel Santiago Anna Hwang Sky Raptentsetsang Brian A. Maruyama Jerry Chen Marissa Cassar Gary Abrams Tatjana Novakovic-Agopian Pratik Mukherjee |
| author_facet | Maria Kryza-Lacombe Rachel Santiago Anna Hwang Sky Raptentsetsang Brian A. Maruyama Jerry Chen Marissa Cassar Gary Abrams Tatjana Novakovic-Agopian Pratik Mukherjee |
| author_sort | Maria Kryza-Lacombe |
| collection | DOAJ |
| description | Mild traumatic brain injury (mTBI) can have lasting consequences on cognitive functioning and well-being. Goal-Oriented Attentional Self-Regulation (GOALS) training has been shown to improve attention and executive functioning, as well as emotional functioning, in veterans with chronic TBI. An ongoing clinical trial (NCT02920788) is further evaluating GOALS training, including underlying neural mechanisms of change. The present study aimed to examine training-induced neuroplasticity by resting-state functional connectivity (rsFC) changes in GOALS versus active control. Veterans with a history of mTBI ?6 months post-injury (N?=?33) were randomly assigned to GOALS (n?=?19) or an intensity-matched active control group (Brain Health Education [BHE] training; n?=?14). GOALS consists of attention regulation and problem solving applied to individually defined, relevant goals through a combination of group, individual, and home practice sessions. Participants underwent multi-band resting-state functional magnetic resonance imaging at baseline and post-intervention. Exploratory 2???2 mixed analyses of variance identified pre-to-post changes in seed-based connectivity for GOALS versus BHE in five significant clusters. GOALS versus BHE demonstrated a significant increase in right lateral pre-frontal cortex connectivity with the right frontal pole and right middle temporal gyrus, as well as increased posterior cingulate connectivity with the pre-central gyrus. Rostral pre-frontal cortex connectivity with the right precuneus and the right frontal pole decreased in GOALS versus BHE. These GOALS-related changes in rsFC point to potential neural mechanisms underlying the intervention. This training-induced neuroplasticity may play a role in improved cognitive and emotional functioning post-GOALS. |
| first_indexed | 2024-03-08T11:28:51Z |
| format | Article |
| id | doaj.art-3ca6ffaca98c4ed281ce27ab289a44fe |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-08T11:28:51Z |
| publishDate | 2023-06-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-3ca6ffaca98c4ed281ce27ab289a44fe2024-01-26T04:40:33ZengMary Ann LiebertNeurotrauma Reports2689-288X2023-06-014142043210.1089/NEUR.2022.0074Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled TrialMaria Kryza-LacombeRachel SantiagoAnna HwangSky RaptentsetsangBrian A. MaruyamaJerry ChenMarissa CassarGary AbramsTatjana Novakovic-AgopianPratik MukherjeeMild traumatic brain injury (mTBI) can have lasting consequences on cognitive functioning and well-being. Goal-Oriented Attentional Self-Regulation (GOALS) training has been shown to improve attention and executive functioning, as well as emotional functioning, in veterans with chronic TBI. An ongoing clinical trial (NCT02920788) is further evaluating GOALS training, including underlying neural mechanisms of change. The present study aimed to examine training-induced neuroplasticity by resting-state functional connectivity (rsFC) changes in GOALS versus active control. Veterans with a history of mTBI ?6 months post-injury (N?=?33) were randomly assigned to GOALS (n?=?19) or an intensity-matched active control group (Brain Health Education [BHE] training; n?=?14). GOALS consists of attention regulation and problem solving applied to individually defined, relevant goals through a combination of group, individual, and home practice sessions. Participants underwent multi-band resting-state functional magnetic resonance imaging at baseline and post-intervention. Exploratory 2???2 mixed analyses of variance identified pre-to-post changes in seed-based connectivity for GOALS versus BHE in five significant clusters. GOALS versus BHE demonstrated a significant increase in right lateral pre-frontal cortex connectivity with the right frontal pole and right middle temporal gyrus, as well as increased posterior cingulate connectivity with the pre-central gyrus. Rostral pre-frontal cortex connectivity with the right precuneus and the right frontal pole decreased in GOALS versus BHE. These GOALS-related changes in rsFC point to potential neural mechanisms underlying the intervention. This training-induced neuroplasticity may play a role in improved cognitive and emotional functioning post-GOALS.https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0074clinical trialcognitive rehabilitationfMRIresting-statetraumatic brain injury |
| spellingShingle | Maria Kryza-Lacombe Rachel Santiago Anna Hwang Sky Raptentsetsang Brian A. Maruyama Jerry Chen Marissa Cassar Gary Abrams Tatjana Novakovic-Agopian Pratik Mukherjee Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial Neurotrauma Reports clinical trial cognitive rehabilitation fMRI resting-state traumatic brain injury |
| title | Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial |
| title_full | Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial |
| title_fullStr | Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial |
| title_full_unstemmed | Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial |
| title_short | Resting-State Connectivity Changes After Goal-Oriented Attentional Self-Regulation Training in Veterans With Mild Traumatic Brain Injury: Preliminary Findings from a Randomized Controlled Trial |
| title_sort | resting state connectivity changes after goal oriented attentional self regulation training in veterans with mild traumatic brain injury preliminary findings from a randomized controlled trial |
| topic | clinical trial cognitive rehabilitation fMRI resting-state traumatic brain injury |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0074 |
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