Amygdalin Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE Knock-Out Mice and Bone Marrow-Derived Macrophages

Amygdalin Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE Knock-Out Mice and Bone Marrow-Derived Macrophages

Amygdalin, the main component of Prunus persica (L.) Stokes, has been used to treat atherosclerosis in mouse model due to its anti-inflammatory role. However, the underlying mechanism remains poorly understood. This study aimed to evidence the influence of amygdalin on high-fat diet-induced atherosc...

Full description

Bibliographic Details
Main Authors:	Yiru Wang, Qingyun Jia, Yifan Zhang, Jing Wei, Ping Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Series:	Frontiers in Pharmacology
Subjects:	atherosclerosis inflammation MAPKs NF-κB p65 amygdalin AP-1
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.590929/full

Similar Items

Taoren Honghua Drug Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE Knock-Out Mice and RAW264.7 Cells
by: Yiru Wang, et al.
Published: (2020-07-01)

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response
by: Zeng Q, et al.
Published: (2023-08-01)

Histological analysis of femoral bones in rabbits administered by amygdalin
by: Veronika Kováčová, et al.
Published: (2016-07-01)

The Pharmacological Activities and Toxicological Effects of Amygdalin: A Review
by: Fatemeh Shaki, et al.
Published: (2022-12-01)

Effects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation
by: Pan Y, et al.
Published: (2023-02-01)

Colony-Level Effects of Amygdalin on Honeybees and Their Microbes
by: James P. Tauber, et al.
Published: (2020-11-01)

Inflammation, It’s Regulation and Antiphlogistic Effect of the Cyanogenic Glycoside Amygdalin
by: Daniela Figurová, et al.
Published: (2021-10-01)

Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin
by: Qiuyu Wen, et al.
Published: (2022-11-01)

Amygdalin as a chemoprotective agent in co-treatment with cisplatin
by: Panayiota Christodoulou, et al.
Published: (2022-09-01)

In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cancer Therapy
by: Fatma I. Abo El-Ela, et al.
Published: (2022-10-01)

Corrigendum: Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin
by: Qiuyu Wen, et al.
Published: (2023-11-01)

Astragaloside IV Relieves Atherosclerosis and Hepatic Steatosis via MAPK/NF-κB Signaling Pathway in LDLR−/− Mice
by: Yifan Zhang, et al.
Published: (2022-02-01)

Oral and intramuscular application of cyanogenic glycoside amygdalin did not induce changes in haematological profile of male rabbits
by: Katarína Zbyňovská, et al.
Published: (2017-01-01)

The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction
by: Adriana Kolesarova, et al.
Published: (2021-08-01)

Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis
by: Fang Hu, et al.
Published: (2019-03-01)

MAPKs/AP-1, not NF-κB, is responsible for MCP-1 production in TNF-α-activated adipocytes
by: Xiaoyu Zhang, et al.
Published: (2022-12-01)

Amygdalin inhibits angiogenesis in the cultured endothelial cells of diabetic rats
by: Hossein Mirmiranpour, et al.
Published: (2012-01-01)

Co-administration of amygdalin and deoxynivalenol disrupted regulatory proteins linked to proliferation of porcine ovarian cells in vitro
by: Marek Halenár, et al.
Published: (2017-01-01)

Isomerization and Stabilization of Amygdalin from Peach Kernels
by: Decai Zhang, et al.
Published: (2023-06-01)

Antioxidant, Anti-Inflammatory, and Anti-Cancer Properties of Amygdalin Extracted from Three Cassava Varieties Cultivated in Benin
by: Halfane Lehmane, et al.
Published: (2023-06-01)

Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction
by: Nguyen Minh Trang, et al.
Published: (2022-02-01)

Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells
by: Valentina Cecarini, et al.
Published: (2022-11-01)

Analysis of Amygdalin in Various Matrices Using Electrospray Ionization and Flowing Atmospheric-Pressure Afterglow Mass Spectrometry
by: Maria Guć, et al.
Published: (2020-10-01)

Mussel oil is superior to fish oil in preventing atherosclerosis of ApoE−/− mice
by: Kelei Li, et al.
Published: (2024-02-01)

Encapsulation of Benzaldehyde Produced by the Eco-Friendly Degradation of Amygdalin in the Apricot Kernel Debitterizing Wastewater
by: Lei Song, et al.
Published: (2024-01-01)

Aqueous two-phase system for the extraction of amygdalin from the debitterized water of apricot kernels
by: Ning Zhang, et al.
Published: (2019-01-01)

Assessment of the cytotoxic effect of carboxymethyl chitosan-loaded amygdalin nanoparticles against human normal and cancer cell lines
by: A. S. El-Houssiny, et al.
Published: (2024-04-01)

Solubility, Solution Thermodynamics, and Preferential Solvation of Amygdalin in Ethanol + Water Solvent Mixtures
by: Abdelkarim Aydi, et al.
Published: (2020-11-01)

Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation
by: Hassan Barakat, et al.
Published: (2022-10-01)

Extraction and Determination of Amygdaline in Iraqi Plant Seeds Using the Combined Simple Extraction Procedure and High-Performance Liquid Chromatography
by: Baghdad Science Journal
Published: (2013-06-01)

Apricot Kernel Extract and Amygdalin Inhibit Urban Particulate Matter-Induced Keratoconjunctivitis Sicca
by: Soo-Wang Hyun, et al.
Published: (2019-02-01)

Sialic acid exerts anti-inflammatory effect through inhibiting MAPK-NF-κB/AP-1 pathway and apoptosis in ulcerative colitis
by: Dan Li, et al.
Published: (2023-02-01)

Synthesis, characterization of inclusion compounds of amygdalin with β-cyclodextrin and sod-like activity and cytotoxicity on hela tumor cells
by: Eleonora Marian, et al.
Published: (2020-08-01)

Punica granatum and amygdalin extracts plus cobalamin combined with albendazole reduce larval burden and myositis in experimental trichinosis
by: Marwa Esmat, et al.
Published: (2021-11-01)

Interactions Between Ephedra sinica and Prunus armeniaca: From Stereoselectivity to Deamination as a Metabolic Detoxification Mechanism of Amygdalin
by: Yan Qin, et al.
Published: (2021-11-01)

Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
by: Ewa Jaszczak-Wilke, et al.
Published: (2021-04-01)

Amygdalin isolated from Amygdalus mongolica protects against hepatic fibrosis in rats
by: Wang Jia, et al.
Published: (2021-09-01)

The pharmacological effect of apricot seeds extracts and amygdalin in experimentally induced liver damage and hepatocellular carcinoma
by: Amer Ramadan, et al.
Published: (2020-10-01)

Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine
by: Ahmed S. Farhan
Published: (2016-06-01)

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review
by: Jiamin Shi, et al.
Published: (2019-06-01)