Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains
Clinical experience suggests that acute postoperative pain after radical surgery for breast cancer can be managed by bupivacaine irrigation. This prospective randomized double blind controlled study was designed to test the hypothesis that bupivacaine irrigation will reduce the 24 hour requirement o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2008;volume=52;issue=2;spage=164;epage=169;aulast=KhanJoad |
| _version_ | 1819206811738177536 |
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| author | Anjum S KhanJoad Pushplata Gupta Malati Tiwari Sanjeev Patni |
| author_facet | Anjum S KhanJoad Pushplata Gupta Malati Tiwari Sanjeev Patni |
| author_sort | Anjum S KhanJoad |
| collection | DOAJ |
| description | Clinical experience suggests that acute postoperative pain after radical surgery for breast cancer can be managed by bupivacaine irrigation. This prospective randomized double blind controlled study was designed to test the hypothesis that bupivacaine irrigation will reduce the 24 hour requirement of tramadol (400 mg + 100 mg) by one fourth (100+25mg).
Forty six patients were allocated randomly to receive intravenous tramadol (Group T) (0.25mg.kg -1 .hr -1 ) and bupivacaine drain irrigation(Group B) (0.4% 20 ml 8 hourly) for postoperative pain. Pain was monitored independently by the APS and PACU nursing staff. APS residents were allowed to give intravenous boluses of tramadol of 50 mg on complaints of pain. Pain scores, nausea, vomiting, sedation, urinary retention ECG and haemodynamic changes were monitored for 24 hours and analysed by Mann-Whitney u test and Fisher′s exact test.
Both groups had good pain relief. The T group had significantly more nausea (P< 0.007). The T group patients had a higher incidence of vomiting, catheterisation and delayed oral intake, but this was not significant statistically. Bupivacaine administered through the surgical drain offered equivalent postoperative pain relief to intravenous tramadol, with significantly less nausea. |
| first_indexed | 2024-12-23T05:13:32Z |
| format | Article |
| id | doaj.art-3ca7abaeb4b649f480a77244f319a540 |
| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-23T05:13:32Z |
| publishDate | 2008-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-3ca7abaeb4b649f480a77244f319a5402022-12-21T17:58:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492008-01-01522164169Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical DrainsAnjum S KhanJoadPushplata GuptaMalati TiwariSanjeev PatniClinical experience suggests that acute postoperative pain after radical surgery for breast cancer can be managed by bupivacaine irrigation. This prospective randomized double blind controlled study was designed to test the hypothesis that bupivacaine irrigation will reduce the 24 hour requirement of tramadol (400 mg + 100 mg) by one fourth (100+25mg). Forty six patients were allocated randomly to receive intravenous tramadol (Group T) (0.25mg.kg -1 .hr -1 ) and bupivacaine drain irrigation(Group B) (0.4% 20 ml 8 hourly) for postoperative pain. Pain was monitored independently by the APS and PACU nursing staff. APS residents were allowed to give intravenous boluses of tramadol of 50 mg on complaints of pain. Pain scores, nausea, vomiting, sedation, urinary retention ECG and haemodynamic changes were monitored for 24 hours and analysed by Mann-Whitney u test and Fisher′s exact test. Both groups had good pain relief. The T group had significantly more nausea (P< 0.007). The T group patients had a higher incidence of vomiting, catheterisation and delayed oral intake, but this was not significant statistically. Bupivacaine administered through the surgical drain offered equivalent postoperative pain relief to intravenous tramadol, with significantly less nausea.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2008;volume=52;issue=2;spage=164;epage=169;aulast=KhanJoadLocal anaesthetic; Acute;Post-mastectomy pain; Randomised controlled trial. |
| spellingShingle | Anjum S KhanJoad Pushplata Gupta Malati Tiwari Sanjeev Patni Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains Indian Journal of Anaesthesia Local anaesthetic; Acute;Post-mastectomy pain; Randomised controlled trial. |
| title | Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains |
| title_full | Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains |
| title_fullStr | Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains |
| title_full_unstemmed | Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains |
| title_short | Acute Post Mastectomy Pain: A Double Blind Randomised Controlled Trial: Intravenous Tramadol Vs Bupivacaine Irrigation through Surgical Drains |
| title_sort | acute post mastectomy pain a double blind randomised controlled trial intravenous tramadol vs bupivacaine irrigation through surgical drains |
| topic | Local anaesthetic; Acute;Post-mastectomy pain; Randomised controlled trial. |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2008;volume=52;issue=2;spage=164;epage=169;aulast=KhanJoad |
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