Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection
Congenital cytomegalovirus infection (cCMV) is the most common intrauterine infection with central nervous system (CNS) involvement. There is limited data on the associations between Single Nucleotide Polymorphisms (SNPs) in genes involving the first-line defense mechanism and the risk of CNS damage...
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2021-09-01
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1783 |
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| author | Justyna Czech-Kowalska Dominika Jedlińska-Pijanowska Agata K. Pleskaczyńska Anna Niezgoda Kinga Gradowska Aleksandra Pietrzyk Elżbieta Jurkiewicz Maciej Jaworski Beata Kasztelewicz |
| author_facet | Justyna Czech-Kowalska Dominika Jedlińska-Pijanowska Agata K. Pleskaczyńska Anna Niezgoda Kinga Gradowska Aleksandra Pietrzyk Elżbieta Jurkiewicz Maciej Jaworski Beata Kasztelewicz |
| author_sort | Justyna Czech-Kowalska |
| collection | DOAJ |
| description | Congenital cytomegalovirus infection (cCMV) is the most common intrauterine infection with central nervous system (CNS) involvement. There is limited data on the associations between Single Nucleotide Polymorphisms (SNPs) in genes involving the first-line defense mechanism and the risk of CNS damage during cCMV. We investigated the associations between neuroimaging findings and SNPs in genes encoding the following cytokines and cytokine receptors in 92 infants with cCMV: interleukins (IL1B rs16944, IL12B rs3212227, IL28B rs12979860), C-C motif chemokine ligand 2 (CCL2 rs1024611), dendritic cell-specific intercellular adhesion grabbing non-integrin (DC-SIGN rs735240), Toll-like receptors (TLR2 rs5743708, TLR4 rs4986791, TLR9 rs352140). The SNP of IL1B rs16944 (G/A) was associated with a reduced risk of ventriculomegaly on MRI (OR = 0.46, 95% CI, 0.22–0.95; <i>p</i> = 0.03) and cUS (OR = 0.38, 95% CI, 0.0–0.93; <i>p</i> = 0.034). Infants carrying heterozygous (T/C) genotype at IL28B rs12979860 had an increased risk of cystic lesions on cUS (OR = 3.31, 95% CI, 1.37–8.01; <i>p</i> = 0.0064) and MRI (OR = 4.97, 95% CI, 1.84–13.43; <i>p</i> = 0.001), and an increased risk of ventriculomegaly on MRI (OR = 2.46, 95% CI, 1.03–5.90; <i>p</i> = 0.04). No other associations between genotyped SNPs and neuroimaging results were found. This is the first study demonstrating new associations between SNPs of IL1B and IL28B and abnormal neuroimaging in infants with cCMV. |
| first_indexed | 2024-03-10T07:08:29Z |
| format | Article |
| id | doaj.art-3ca8124037ab4df68eb61ee5193bab75 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:08:29Z |
| publishDate | 2021-09-01 |
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| series | Viruses |
| spelling | doaj.art-3ca8124037ab4df68eb61ee5193bab752023-11-22T15:37:55ZengMDPI AGViruses1999-49152021-09-01139178310.3390/v13091783Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV InfectionJustyna Czech-Kowalska0Dominika Jedlińska-Pijanowska1Agata K. Pleskaczyńska2Anna Niezgoda3Kinga Gradowska4Aleksandra Pietrzyk5Elżbieta Jurkiewicz6Maciej Jaworski7Beata Kasztelewicz8Neonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandNeonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandNeonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandNeonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandNeonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandNeonatal Intensive Care Unit, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Diagnostic Imaging, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Clinical Microbiology and Immunology, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandCongenital cytomegalovirus infection (cCMV) is the most common intrauterine infection with central nervous system (CNS) involvement. There is limited data on the associations between Single Nucleotide Polymorphisms (SNPs) in genes involving the first-line defense mechanism and the risk of CNS damage during cCMV. We investigated the associations between neuroimaging findings and SNPs in genes encoding the following cytokines and cytokine receptors in 92 infants with cCMV: interleukins (IL1B rs16944, IL12B rs3212227, IL28B rs12979860), C-C motif chemokine ligand 2 (CCL2 rs1024611), dendritic cell-specific intercellular adhesion grabbing non-integrin (DC-SIGN rs735240), Toll-like receptors (TLR2 rs5743708, TLR4 rs4986791, TLR9 rs352140). The SNP of IL1B rs16944 (G/A) was associated with a reduced risk of ventriculomegaly on MRI (OR = 0.46, 95% CI, 0.22–0.95; <i>p</i> = 0.03) and cUS (OR = 0.38, 95% CI, 0.0–0.93; <i>p</i> = 0.034). Infants carrying heterozygous (T/C) genotype at IL28B rs12979860 had an increased risk of cystic lesions on cUS (OR = 3.31, 95% CI, 1.37–8.01; <i>p</i> = 0.0064) and MRI (OR = 4.97, 95% CI, 1.84–13.43; <i>p</i> = 0.001), and an increased risk of ventriculomegaly on MRI (OR = 2.46, 95% CI, 1.03–5.90; <i>p</i> = 0.04). No other associations between genotyped SNPs and neuroimaging results were found. This is the first study demonstrating new associations between SNPs of IL1B and IL28B and abnormal neuroimaging in infants with cCMV.https://www.mdpi.com/1999-4915/13/9/1783human cytomegalovirus (HCMV)congenital CMV infectioncentral nervous systeminterleukins (IL1BILB28)toll-like receptor (TLR) |
| spellingShingle | Justyna Czech-Kowalska Dominika Jedlińska-Pijanowska Agata K. Pleskaczyńska Anna Niezgoda Kinga Gradowska Aleksandra Pietrzyk Elżbieta Jurkiewicz Maciej Jaworski Beata Kasztelewicz Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection Viruses human cytomegalovirus (HCMV) congenital CMV infection central nervous system interleukins (IL1B ILB28) toll-like receptor (TLR) |
| title | Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection |
| title_full | Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection |
| title_fullStr | Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection |
| title_full_unstemmed | Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection |
| title_short | Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection |
| title_sort | single nucleotide polymorphisms of interleukins and toll like receptors and neuroimaging results in newborns with congenital hcmv infection |
| topic | human cytomegalovirus (HCMV) congenital CMV infection central nervous system interleukins (IL1B ILB28) toll-like receptor (TLR) |
| url | https://www.mdpi.com/1999-4915/13/9/1783 |
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