Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients.Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed...
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00265/full |
| _version_ | 1818096272579493888 |
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| author | Jingxin Mao Jingxin Mao Qinghai Zhang Qinghai Zhang Haiyan Zhang Ke Zheng Rui Wang Guoze Wang Guoze Wang |
| author_facet | Jingxin Mao Jingxin Mao Qinghai Zhang Qinghai Zhang Haiyan Zhang Ke Zheng Rui Wang Guoze Wang Guoze Wang |
| author_sort | Jingxin Mao |
| collection | DOAJ |
| description | Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients.Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020.Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14–2.01, p <0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51–1.87, p <0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45–2.89, p <0.0001); tumor size ≥1.0 cm (pooled OR = 3.53, 95% CI = 2.62–4.76, p <0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04–2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69–7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78–2.31, p <0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54–1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79–1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients.Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer. |
| first_indexed | 2024-12-10T23:01:59Z |
| format | Article |
| id | doaj.art-3ca83c39732c42ecad84211d263d9c8a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T23:01:59Z |
| publishDate | 2020-05-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-3ca83c39732c42ecad84211d263d9c8a2022-12-22T01:30:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-05-011110.3389/fendo.2020.00265528980Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-AnalysisJingxin Mao0Jingxin Mao1Qinghai Zhang2Qinghai Zhang3Haiyan Zhang4Ke Zheng5Rui Wang6Guoze Wang7Guoze Wang8School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaCollege of Food Science, Guizhou Medical University, Guiyang, ChinaInstitute of Deep-Sea Science and Engineering, Chinese Academy of Science, Sanya, ChinaDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacology, College of Pharmacy, Guilin Medical University, Guilin, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaCollege of Food Science, Guizhou Medical University, Guiyang, ChinaPurpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients.Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020.Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14–2.01, p <0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51–1.87, p <0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45–2.89, p <0.0001); tumor size ≥1.0 cm (pooled OR = 3.53, 95% CI = 2.62–4.76, p <0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04–2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69–7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78–2.31, p <0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54–1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79–1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients.Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.https://www.frontiersin.org/article/10.3389/fendo.2020.00265/fullpapillary thyroid carcinoma (PTC)lymph node metastasis (LNM)risk factorprognostic factormeta-analysis |
| spellingShingle | Jingxin Mao Jingxin Mao Qinghai Zhang Qinghai Zhang Haiyan Zhang Ke Zheng Rui Wang Guoze Wang Guoze Wang Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis Frontiers in Endocrinology papillary thyroid carcinoma (PTC) lymph node metastasis (LNM) risk factor prognostic factor meta-analysis |
| title | Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | risk factors for lymph node metastasis in papillary thyroid carcinoma a systematic review and meta analysis |
| topic | papillary thyroid carcinoma (PTC) lymph node metastasis (LNM) risk factor prognostic factor meta-analysis |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00265/full |
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