Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio (non-homology-based) structure prediction. Such m...

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Bibliographic Details
Main Authors: Felix Simkovic, Jens M. H. Thomas, Ronan M. Keegan, Martyn D. Winn, Olga Mayans, Daniel J. Rigden
Format: Article
Language:English
Published: International Union of Crystallography 2016-07-01
Series:IUCrJ
Subjects:
molecular replacement
protein structure prediction
evolutionary covariation
predicted contacts
ab initio modelling
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252516008113

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