LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer’s and Parkinson’s Disease-Related Neuroinflammation

LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer’s and Parkinson’s Disease-Related Neuroinflammation

Chronic neuroinflammation plays a crucial role in the progression of several neurodegenerative diseases (NDDs), including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Intriguingly, in the last decade, leucine-rich repeat kinase-2 (<i>LRRK2</i>), a gene mutated in familial and s...

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Bibliographic Details
Main Authors: Veronica Mutti, Giulia Carini, Alice Filippini, Stefania Castrezzati, Lorena Giugno, Massimo Gennarelli, Isabella Russo
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
LRRK2
inhibitor
neuroinflammation
Parkinson’s disease
Alzheimer’s disease
Online Access:https://www.mdpi.com/2073-4409/12/13/1799

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