Poly ADP-Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death

Poly ADP-Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death

Introduction: Poly ADP-Ribose Polymerase-1 (PARP1), a DNA repair enzyme is implicated as a key molecule in the pathogenesis of several neurodegenerative disorders. Traumatic insults inducing oxidative stress results in its over-activation causing inflammation and cell death (Parthanatos). As PARP1 i...

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Bibliographic Details
Main Authors: Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Supriya D. Mahajan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
in vitro blast injury model
PARP (poly(ADP-ribose) polymerase
3-aminobenzamide
cell death
HEI-OC1 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1047308/full

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