Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting.
In this study, we present first data concerning the anatomical structure, blood supply and location of the lacrimal gland of the pig. Our data indicate that the porcine lacrimal gland may serve as a potential xenograft candidate in humans or as an animal model for engineering of a bioartificial lacr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3771908?pdf=render |
| _version_ | 1818924072297299968 |
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| author | Robert Henker Michael Scholz Simone Gaffling Nagayoshi Asano Ulrike Hampel Fabian Garreis Joachim Hornegger Friedrich Paulsen |
| author_facet | Robert Henker Michael Scholz Simone Gaffling Nagayoshi Asano Ulrike Hampel Fabian Garreis Joachim Hornegger Friedrich Paulsen |
| author_sort | Robert Henker |
| collection | DOAJ |
| description | In this study, we present first data concerning the anatomical structure, blood supply and location of the lacrimal gland of the pig. Our data indicate that the porcine lacrimal gland may serve as a potential xenograft candidate in humans or as an animal model for engineering of a bioartificial lacrimal gland tissue construct for clinical application. For this purpose, we used different macroscopic preparation techniques and digital reconstruction of the histological gland morphology to gain new insights and important information concerning the feasibility of a lacrimal gland transplantation from pig to humans in general. Our results show that the lacrimal gland of the pig reveals a lot of morphological similarities to the analogous human lacrimal gland and thus might be regarded as a xenograft in the future. This is true for a similar anatomical location within the orbit as well as for the feeding artery supply to the organ. Functional differences concerning the composition of the tear fluid, due to a different secretory unit distribution within the gland tissue will, however, be a challenge in future investigations. |
| first_indexed | 2024-12-20T02:19:31Z |
| format | Article |
| id | doaj.art-3cafb6767daa447784f6911ffb8e11b3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T02:19:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3cafb6767daa447784f6911ffb8e11b32022-12-21T19:56:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7404610.1371/journal.pone.0074046Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting.Robert HenkerMichael ScholzSimone GafflingNagayoshi AsanoUlrike HampelFabian GarreisJoachim HorneggerFriedrich PaulsenIn this study, we present first data concerning the anatomical structure, blood supply and location of the lacrimal gland of the pig. Our data indicate that the porcine lacrimal gland may serve as a potential xenograft candidate in humans or as an animal model for engineering of a bioartificial lacrimal gland tissue construct for clinical application. For this purpose, we used different macroscopic preparation techniques and digital reconstruction of the histological gland morphology to gain new insights and important information concerning the feasibility of a lacrimal gland transplantation from pig to humans in general. Our results show that the lacrimal gland of the pig reveals a lot of morphological similarities to the analogous human lacrimal gland and thus might be regarded as a xenograft in the future. This is true for a similar anatomical location within the orbit as well as for the feeding artery supply to the organ. Functional differences concerning the composition of the tear fluid, due to a different secretory unit distribution within the gland tissue will, however, be a challenge in future investigations.http://europepmc.org/articles/PMC3771908?pdf=render |
| spellingShingle | Robert Henker Michael Scholz Simone Gaffling Nagayoshi Asano Ulrike Hampel Fabian Garreis Joachim Hornegger Friedrich Paulsen Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. PLoS ONE |
| title | Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. |
| title_full | Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. |
| title_fullStr | Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. |
| title_full_unstemmed | Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. |
| title_short | Morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting. |
| title_sort | morphological features of the porcine lacrimal gland and its compatibility for human lacrimal gland xenografting |
| url | http://europepmc.org/articles/PMC3771908?pdf=render |
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