Islet Transplantation Imaging in vivo
Lei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/islet-transplantation-imaging-in-vivo-peer-reviewed-article-DMSO |
| _version_ | 1828046378662625280 |
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| author | Zheng L Wang Y Yang B Zhang B Wu Y |
| author_facet | Zheng L Wang Y Yang B Zhang B Wu Y |
| author_sort | Zheng L |
| collection | DOAJ |
| description | Lei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Zhang; Yulian WuDepartment of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of ChinaTel/ Fax +86 571 87783563Email jjs10@zju.edu.cn; yulianwu@zju.edu.cnAbstract: Although islet transplantation plays an effective and powerful role in the treatment of diabetes, a large amount of islet grafts are lost at an early stage due to instant blood-mediated inflammatory reactions, immune rejection, and β-cell toxicity resulting from immunosuppressive agents. Timely intervention based on the viability and function of the transplanted islets at an early stage is crucial. Various islet transplantation imaging techniques are available for monitoring the conditions of post-transplanted islets. Due to the development of various imaging modalities and the continuous study of contrast agents, non-invasive islet transplantation imaging in vivo has made great progress. The tracing and functional evaluation of transplanted islets in vivo have thus become possible. However, most studies on contrast agent and imaging modalities are limited to animal experiments, and long-term toxicity and stability need further evaluation. Accordingly, the clinical application of the current achievements still requires a large amount of effort. In this review, we discuss the contrast agents for MRI, SPECT/PET, BLI/FI, US, MPI, PAI, and multimodal imaging. We further summarize the advantages and limitations of various molecular imaging methods.Keywords: islet transplantation, imaging modality, non-invasive imaging, multimodal imaging, contrast agent |
| first_indexed | 2024-04-10T18:25:22Z |
| format | Article |
| id | doaj.art-3cb2803d488f4c08abd7dccf6d2f5f3f |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:25:22Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-3cb2803d488f4c08abd7dccf6d2f5f3f2023-02-02T05:52:27ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-09-01Volume 133301331157273Islet Transplantation Imaging in vivoZheng LWang YYang BZhang BWu YLei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Zhang; Yulian WuDepartment of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of ChinaTel/ Fax +86 571 87783563Email jjs10@zju.edu.cn; yulianwu@zju.edu.cnAbstract: Although islet transplantation plays an effective and powerful role in the treatment of diabetes, a large amount of islet grafts are lost at an early stage due to instant blood-mediated inflammatory reactions, immune rejection, and β-cell toxicity resulting from immunosuppressive agents. Timely intervention based on the viability and function of the transplanted islets at an early stage is crucial. Various islet transplantation imaging techniques are available for monitoring the conditions of post-transplanted islets. Due to the development of various imaging modalities and the continuous study of contrast agents, non-invasive islet transplantation imaging in vivo has made great progress. The tracing and functional evaluation of transplanted islets in vivo have thus become possible. However, most studies on contrast agent and imaging modalities are limited to animal experiments, and long-term toxicity and stability need further evaluation. Accordingly, the clinical application of the current achievements still requires a large amount of effort. In this review, we discuss the contrast agents for MRI, SPECT/PET, BLI/FI, US, MPI, PAI, and multimodal imaging. We further summarize the advantages and limitations of various molecular imaging methods.Keywords: islet transplantation, imaging modality, non-invasive imaging, multimodal imaging, contrast agenthttps://www.dovepress.com/islet-transplantation-imaging-in-vivo-peer-reviewed-article-DMSOislet transplantationimaging modalitynon-invasive imagingmultimodal imagingcontrast agent |
| spellingShingle | Zheng L Wang Y Yang B Zhang B Wu Y Islet Transplantation Imaging in vivo Diabetes, Metabolic Syndrome and Obesity islet transplantation imaging modality non-invasive imaging multimodal imaging contrast agent |
| title | Islet Transplantation Imaging in vivo |
| title_full | Islet Transplantation Imaging in vivo |
| title_fullStr | Islet Transplantation Imaging in vivo |
| title_full_unstemmed | Islet Transplantation Imaging in vivo |
| title_short | Islet Transplantation Imaging in vivo |
| title_sort | islet transplantation imaging in vivo |
| topic | islet transplantation imaging modality non-invasive imaging multimodal imaging contrast agent |
| url | https://www.dovepress.com/islet-transplantation-imaging-in-vivo-peer-reviewed-article-DMSO |
| work_keys_str_mv | AT zhengl islettransplantationimaginginvivo AT wangy islettransplantationimaginginvivo AT yangb islettransplantationimaginginvivo AT zhangb islettransplantationimaginginvivo AT wuy islettransplantationimaginginvivo |