Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223–3p/NLRP3 axis

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223–3p/NLRP3 axis

Silicosis is a progressive inflammatory disease with poorly defined mechanisms and limited therapeutic options. Recent studies found that microRNAs (miRNAs) and circular RNAs (circRNAs) were involved in the development of respiratory diseases; however, the function of non-coding RNAs in silicosis wa...

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Bibliographic Details
Main Authors: Lin Hou, Zhonghui Zhu, Fuyang Jiang, Jing Zhao, Qiyue Jia, Qiyue Jiang, Hongwei Wang, Wenming Xue, Yan Wang, Lin Tian
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Silicosis
Pulmonary fibrosis
CircPWWP2A
MiRNA-223–3p
NLRP3 inflammasome
HucMSC-EVs
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323000416

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