Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07405-5 |
| _version_ | 1818342621200777216 |
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| author | Xianwei Wang Hui Peng Jingjing Cong Xuefu Wang Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian |
| author_facet | Xianwei Wang Hui Peng Jingjing Cong Xuefu Wang Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian |
| author_sort | Xianwei Wang |
| collection | DOAJ |
| description | Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7 dependent survival and memory maintenance. |
| first_indexed | 2024-12-13T16:17:36Z |
| format | Article |
| id | doaj.art-3cb3684889cd478cbcbe3f0f21c7399c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:17:36Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3cb3684889cd478cbcbe3f0f21c7399c2022-12-21T23:38:49ZengNature PortfolioNature Communications2041-17232018-11-019111210.1038/s41467-018-07405-5Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axisXianwei Wang0Hui Peng1Jingjing Cong2Xuefu Wang3Zhexiong Lian4Haiming Wei5Rui Sun6Zhigang Tian7Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaNatural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7 dependent survival and memory maintenance.https://doi.org/10.1038/s41467-018-07405-5 |
| spellingShingle | Xianwei Wang Hui Peng Jingjing Cong Xuefu Wang Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis Nature Communications |
| title | Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis |
| title_full | Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis |
| title_fullStr | Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis |
| title_full_unstemmed | Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis |
| title_short | Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis |
| title_sort | memory formation and long term maintenance of il 7rα ilc1s via a lymph node liver axis |
| url | https://doi.org/10.1038/s41467-018-07405-5 |
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