KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner

KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner

Abstract Background KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers including non-small cell lung cancer (NSCLC) and colorectal cancer. Although KRAS was considered undruggable until recently, several KRAS inhi...

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Bibliographic Details
Main Authors: Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini, Eric Deutsch
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
MRTX1257
Radiotherapy
KRAS inhibitors
Tumor
Radio-sensitizing
KRAS G12C
Online Access:https://doi.org/10.1186/s12967-023-04619-0

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