METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS
It is necessary to elaborate methods of atypical neuroleptic agents detection as individual substances and in different combinations as well for diagnosis of poisoning by some of them: clozapine, risperidone, sertindole, olanzapine, aripiprazole. The purpose of this work is methods elaboration of de...
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| Format: | Article |
| Language: | Russian |
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Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute
2015-09-01
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| Series: | Фармация и фармакология (Пятигорск) |
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| Online Access: | https://www.pharmpharm.ru/jour/article/view/68 |
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| author | I. P. Remezova D. S. Lazaryan T. I. Maksimenko D. Yu. Sanzhieva A. Yu. Rybasova |
| author_facet | I. P. Remezova D. S. Lazaryan T. I. Maksimenko D. Yu. Sanzhieva A. Yu. Rybasova |
| author_sort | I. P. Remezova |
| collection | DOAJ |
| description | It is necessary to elaborate methods of atypical neuroleptic agents detection as individual substances and in different combinations as well for diagnosis of poisoning by some of them: clozapine, risperidone, sertindole, olanzapine, aripiprazole. The purpose of this work is methods elaboration of detection of clozapine, risperidone, sertindole, olanzapine, aripiprazole, haloperidol, oxazepam, carbamazapine using TLC, HPLC and UV spectrophotometry methods. During this work we used tablet forms of clozapine, risperidone, sertindole, olanzapine, aripiprazole. It is possible to use solution systems like ethanol-water-25% ammonia solution (8:1:1), toluolacetone-ethanol-25% ammonia solution (45:45:7.5:2.5), dioxan-chloroform-acetone-25% ammonia solution (47.5:45:5:2.5) for preliminary examination of atypical neuroleptic agents under study in combination with typical neuroleptics and tranquilizers with undirected analysis (general screening). System of solvents ethyl-acetate-chloroform-25% ammonia solution (85:10:5) is recommended to use for individual screening of risperidone, sertindole, olanzapine, haloperidol, benzol-ethanol-25% ammonia solution (50:10:0.5) system to use for clozapine, sertindole, olanzapine. Ethanol-25% ammonia solution (100:1.5) system is reasonable to use for chromatographic clearance of extracts from biological substances under study. We recommend using HPLC method and UV spectrophotometry for carrying out of a principal examination of clozapine, risperidone, sertindole, olanzapine and aripiprazole in case one of the substances under study is determined in the object. |
| first_indexed | 2024-04-10T01:36:46Z |
| format | Article |
| id | doaj.art-3cb942e280a94f9698281326d0215e80 |
| institution | Directory Open Access Journal |
| issn | 2307-9266 2413-2241 |
| language | Russian |
| last_indexed | 2024-04-10T01:36:46Z |
| publishDate | 2015-09-01 |
| publisher | Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute |
| record_format | Article |
| series | Фармация и фармакология (Пятигорск) |
| spelling | doaj.art-3cb942e280a94f9698281326d0215e802023-03-13T09:18:09ZrusVolgograd State Medical University, Pyatigorsk Medical and Pharmaceutical InstituteФармация и фармакология (Пятигорск)2307-92662413-22412015-09-0126(7)545810.19163/2307-9266-2014-2-6(7)-54-5868METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSISI. P. Remezova0D. S. Lazaryan1T. I. Maksimenko2D. Yu. Sanzhieva3A. Yu. Rybasova4Пятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскПятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскПятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскПятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскПятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскIt is necessary to elaborate methods of atypical neuroleptic agents detection as individual substances and in different combinations as well for diagnosis of poisoning by some of them: clozapine, risperidone, sertindole, olanzapine, aripiprazole. The purpose of this work is methods elaboration of detection of clozapine, risperidone, sertindole, olanzapine, aripiprazole, haloperidol, oxazepam, carbamazapine using TLC, HPLC and UV spectrophotometry methods. During this work we used tablet forms of clozapine, risperidone, sertindole, olanzapine, aripiprazole. It is possible to use solution systems like ethanol-water-25% ammonia solution (8:1:1), toluolacetone-ethanol-25% ammonia solution (45:45:7.5:2.5), dioxan-chloroform-acetone-25% ammonia solution (47.5:45:5:2.5) for preliminary examination of atypical neuroleptic agents under study in combination with typical neuroleptics and tranquilizers with undirected analysis (general screening). System of solvents ethyl-acetate-chloroform-25% ammonia solution (85:10:5) is recommended to use for individual screening of risperidone, sertindole, olanzapine, haloperidol, benzol-ethanol-25% ammonia solution (50:10:0.5) system to use for clozapine, sertindole, olanzapine. Ethanol-25% ammonia solution (100:1.5) system is reasonable to use for chromatographic clearance of extracts from biological substances under study. We recommend using HPLC method and UV spectrophotometry for carrying out of a principal examination of clozapine, risperidone, sertindole, olanzapine and aripiprazole in case one of the substances under study is determined in the object.https://www.pharmpharm.ru/jour/article/view/68химико-токсикологический анализатипичные нейролептикиклозапинрисперидонсертиндололанзапинарипипразол |
| spellingShingle | I. P. Remezova D. S. Lazaryan T. I. Maksimenko D. Yu. Sanzhieva A. Yu. Rybasova METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS Фармация и фармакология (Пятигорск) химико-токсикологический анализ атипичные нейролептики клозапин рисперидон сертиндол оланзапин арипипразол |
| title | METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS |
| title_full | METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS |
| title_fullStr | METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS |
| title_full_unstemmed | METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS |
| title_short | METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS |
| title_sort | methods elaboration on detection of some atypical neurolytic agents for chemical and toxicological analysis |
| topic | химико-токсикологический анализ атипичные нейролептики клозапин рисперидон сертиндол оланзапин арипипразол |
| url | https://www.pharmpharm.ru/jour/article/view/68 |
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