Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis
BACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those with portal hypertension without liver cirrhos...
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Fundação Oswaldo Cruz (FIOCRUZ)
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000700469&lng=en&tlng=en |
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| author | Liana Gonçalves-Macedo Edmundo Pessoa Lopes Ana Lucia Coutinho Domingues Brivaldo Markman Filho Vitor Gomes Mota Carlos Feitosa Luna |
| author_facet | Liana Gonçalves-Macedo Edmundo Pessoa Lopes Ana Lucia Coutinho Domingues Brivaldo Markman Filho Vitor Gomes Mota Carlos Feitosa Luna |
| author_sort | Liana Gonçalves-Macedo |
| collection | DOAJ |
| description | BACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those with portal hypertension without liver cirrhosis, as may occur in hepatosplenic schistosomiasis (HSS). OBJECTIVES To investigate the prevalence of HPS in patients with HSS, and to determine whether the occurrence of HPS is influenced by concomitant cirrhosis. METHODS We evaluated patients with HSS with or without concomitant liver cirrhosis. All patients underwent laboratory testing, ultrasound, endoscopy, contrast echocardiography, and arterial blood gas analysis. FINDINGS Of the 121 patients with HSS, 64 were also diagnosed with liver cirrhosis. HPS was diagnosed in 42 patients (35%) and was more frequent among patients with concomitant liver cirrhosis than in those without cirrhosis (42% vs. 26%), but the difference was not significant (p = 0.069). HPS was more common in those with spider naevi, Child-Pugh classes B or C and high model for end stage liver disease (MELD) scores (p < 0.05 each). MAIN CONCLUSIONS The prevalence of HPS was 35% in this study. The occurrence of liver cirrhosis concomitantly with HSS may have influenced the frequency of patients presenting with HPS. |
| first_indexed | 2024-03-12T18:07:16Z |
| format | Article |
| id | doaj.art-3cbaa07c6ad4422d8e88fa7eb5702e4d |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:07:16Z |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-3cbaa07c6ad4422d8e88fa7eb5702e4d2023-08-02T09:28:09ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-8060112746947310.1590/0074-02760160383S0074-02762017000700469Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosisLiana Gonçalves-MacedoEdmundo Pessoa LopesAna Lucia Coutinho DominguesBrivaldo Markman FilhoVitor Gomes MotaCarlos Feitosa LunaBACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those with portal hypertension without liver cirrhosis, as may occur in hepatosplenic schistosomiasis (HSS). OBJECTIVES To investigate the prevalence of HPS in patients with HSS, and to determine whether the occurrence of HPS is influenced by concomitant cirrhosis. METHODS We evaluated patients with HSS with or without concomitant liver cirrhosis. All patients underwent laboratory testing, ultrasound, endoscopy, contrast echocardiography, and arterial blood gas analysis. FINDINGS Of the 121 patients with HSS, 64 were also diagnosed with liver cirrhosis. HPS was diagnosed in 42 patients (35%) and was more frequent among patients with concomitant liver cirrhosis than in those without cirrhosis (42% vs. 26%), but the difference was not significant (p = 0.069). HPS was more common in those with spider naevi, Child-Pugh classes B or C and high model for end stage liver disease (MELD) scores (p < 0.05 each). MAIN CONCLUSIONS The prevalence of HPS was 35% in this study. The occurrence of liver cirrhosis concomitantly with HSS may have influenced the frequency of patients presenting with HPS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000700469&lng=en&tlng=enneglected diseasesportal hypertensionoesophageal and gastric varicesultrasoundschistosomiasishepatopulmonary syndrome |
| spellingShingle | Liana Gonçalves-Macedo Edmundo Pessoa Lopes Ana Lucia Coutinho Domingues Brivaldo Markman Filho Vitor Gomes Mota Carlos Feitosa Luna Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis Memorias do Instituto Oswaldo Cruz neglected diseases portal hypertension oesophageal and gastric varices ultrasound schistosomiasis hepatopulmonary syndrome |
| title | Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis |
| title_full | Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis |
| title_fullStr | Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis |
| title_full_unstemmed | Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis |
| title_short | Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis |
| title_sort | schistosomiasis and hepatopulmonary syndrome the role of concomitant liver cirrhosis |
| topic | neglected diseases portal hypertension oesophageal and gastric varices ultrasound schistosomiasis hepatopulmonary syndrome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000700469&lng=en&tlng=en |
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