The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure
Abstract Non-traumatic subarachnoid hemorrhage (SAH) accounts for 3–5% of acute strokes. Intracranial aneurysm is the most common cause of non-traumatic SAH. Vitamin D influences the cardiovascular system, including the formation and rupture of cerebral aneurysms. To evaluate the serum vitamin D lev...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-53676-y |
| _version_ | 1827327888956850176 |
|---|---|
| author | Lívio Pereira de Macêdo Renata de Castro Tavares Mateus Torres Braga Lidiane Moura dos Santos Glaudir Donato Fábio Antônio Serra de Lima Júnior Rosanne Pereira de Macêdo Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini José Laércio Júnior Silva Eduardo Vieira de Carvalho Júnior Nivaldo S. Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho |
| author_facet | Lívio Pereira de Macêdo Renata de Castro Tavares Mateus Torres Braga Lidiane Moura dos Santos Glaudir Donato Fábio Antônio Serra de Lima Júnior Rosanne Pereira de Macêdo Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini José Laércio Júnior Silva Eduardo Vieira de Carvalho Júnior Nivaldo S. Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho |
| author_sort | Lívio Pereira de Macêdo |
| collection | DOAJ |
| description | Abstract Non-traumatic subarachnoid hemorrhage (SAH) accounts for 3–5% of acute strokes. Intracranial aneurysm is the most common cause of non-traumatic SAH. Vitamin D influences the cardiovascular system, including the formation and rupture of cerebral aneurysms. To evaluate the serum vitamin D level in patients living in the tropical zone who suffered aneurysmal subarachnoid hemorrhage and its correlation with demographic and neurological characteristics. This is an analytical cross-sectional study to assess the serum level of vitamin D in a study population of 99 patients treated and diagnosed with aSAH in a public hospital in Recife-PE over a period of 12 months. In the study sample, composed of individuals with high sun exposure due to the lifestyle they lead in a tropical region, we observed hypovitaminosis D (85.9%), with a median of 19.9 ng/ml, although the majority of individuals are skin with high concentration of melanin (Fitzpatrick skin type IV and V). In addition, rates of sun exposure are high to all patients (Solar Index 9.03 P50). Most individuals were female (79.8%); there was no statistical difference in solar exposure/solar index between genders. As for the neurological repercussions, there was no statistical relevance in the clinical prognostic scales evaluated. As the sample was composed mainly of individuals whose economic activity is agriculture, the values of solar index found are vastly higher than those of other studies conducted in high latitude regions. In line with the literature review, some aspects were raised with the objective of justifying such findings that go from the base of the poor diet of these individuals, the increase of melanin in the skin and genetic alterations that directs us to possible mechanisms of natural photoprotection to high sun exposure. Thus, we had a vast majority (85%) of hypovitaminosis D, which in fact makes us wonder if there is any influence of calcitriol on vitamin D receptors in vascular walls and in the cardiovascular system as a whole, which influence bleeding events of this nature. As for the neurological repercussions, measured using assessment scales (Glasgow coma scale, WFNS scale, Hunt–Hess and Fisher's tomographic scale) there was no significant difference in the results. As it is only a descriptive study, the causal relationship of the facts cannot be established. However, in a population exposed to high sun exposure and affected by aneurysmal SAH, there is a significant rate of hypovitaminosis D, which supports the hypothesis that vitamin D plays a role in vascular pathologies, such as cerebral aneurysms and SAH. |
| first_indexed | 2024-03-07T15:08:57Z |
| format | Article |
| id | doaj.art-3cbb99154c654d57bfea29f701513930 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:08:57Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3cbb99154c654d57bfea29f7015139302024-03-05T18:45:13ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-53676-yThe relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposureLívio Pereira de Macêdo0Renata de Castro Tavares1Mateus Torres Braga2Lidiane Moura dos Santos3Glaudir Donato4Fábio Antônio Serra de Lima Júnior5Rosanne Pereira de Macêdo6Arlindo Ugulino Netto7Kauê Franke8Pierre Vansant Oliveira Eugênio9Auricélio Batista Cezar-Junior10Igor Vilela Faquini11José Laércio Júnior Silva12Eduardo Vieira de Carvalho Júnior13Nivaldo S. Almeida14Francisco Alfredo Bandeira e Farias15Marcelo Moraes Valença16Hildo Rocha Cirne Azevedo-Filho17Department of Neurosurgery, Hospital da RestauraçãoHospital Agamenon MagalhãesUniversidade CatólicaUninassau- PernambucoMedical Student, Centro de Ciências Médicas, Universidade Federal da ParaíbaMedical Student, Centro de Ciências Médicas, Universidade Federal da ParaíbaUnifacid- WydenDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoDepartment of Neurosurgery, Hospital da RestauraçãoHospital Agamenon MagalhãesUniversidade Federal de PernambucoDepartment of Neurosurgery, Hospital da RestauraçãoAbstract Non-traumatic subarachnoid hemorrhage (SAH) accounts for 3–5% of acute strokes. Intracranial aneurysm is the most common cause of non-traumatic SAH. Vitamin D influences the cardiovascular system, including the formation and rupture of cerebral aneurysms. To evaluate the serum vitamin D level in patients living in the tropical zone who suffered aneurysmal subarachnoid hemorrhage and its correlation with demographic and neurological characteristics. This is an analytical cross-sectional study to assess the serum level of vitamin D in a study population of 99 patients treated and diagnosed with aSAH in a public hospital in Recife-PE over a period of 12 months. In the study sample, composed of individuals with high sun exposure due to the lifestyle they lead in a tropical region, we observed hypovitaminosis D (85.9%), with a median of 19.9 ng/ml, although the majority of individuals are skin with high concentration of melanin (Fitzpatrick skin type IV and V). In addition, rates of sun exposure are high to all patients (Solar Index 9.03 P50). Most individuals were female (79.8%); there was no statistical difference in solar exposure/solar index between genders. As for the neurological repercussions, there was no statistical relevance in the clinical prognostic scales evaluated. As the sample was composed mainly of individuals whose economic activity is agriculture, the values of solar index found are vastly higher than those of other studies conducted in high latitude regions. In line with the literature review, some aspects were raised with the objective of justifying such findings that go from the base of the poor diet of these individuals, the increase of melanin in the skin and genetic alterations that directs us to possible mechanisms of natural photoprotection to high sun exposure. Thus, we had a vast majority (85%) of hypovitaminosis D, which in fact makes us wonder if there is any influence of calcitriol on vitamin D receptors in vascular walls and in the cardiovascular system as a whole, which influence bleeding events of this nature. As for the neurological repercussions, measured using assessment scales (Glasgow coma scale, WFNS scale, Hunt–Hess and Fisher's tomographic scale) there was no significant difference in the results. As it is only a descriptive study, the causal relationship of the facts cannot be established. However, in a population exposed to high sun exposure and affected by aneurysmal SAH, there is a significant rate of hypovitaminosis D, which supports the hypothesis that vitamin D plays a role in vascular pathologies, such as cerebral aneurysms and SAH.https://doi.org/10.1038/s41598-024-53676-ySerum vitamin DAneurysmal subarachnoid hemorrhageTropical zone |
| spellingShingle | Lívio Pereira de Macêdo Renata de Castro Tavares Mateus Torres Braga Lidiane Moura dos Santos Glaudir Donato Fábio Antônio Serra de Lima Júnior Rosanne Pereira de Macêdo Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini José Laércio Júnior Silva Eduardo Vieira de Carvalho Júnior Nivaldo S. Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure Scientific Reports Serum vitamin D Aneurysmal subarachnoid hemorrhage Tropical zone |
| title | The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure |
| title_full | The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure |
| title_fullStr | The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure |
| title_full_unstemmed | The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure |
| title_short | The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure |
| title_sort | relationship between the level of vitamin d and ruptured intracranial aneurysms among patients with high sun exposure |
| topic | Serum vitamin D Aneurysmal subarachnoid hemorrhage Tropical zone |
| url | https://doi.org/10.1038/s41598-024-53676-y |
| work_keys_str_mv | AT liviopereirademacedo therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT renatadecastrotavares therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT mateustorresbraga therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT lidianemouradossantos therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT glaudirdonato therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT fabioantonioserradelimajunior therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT rosannepereirademacedo therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT arlindougulinonetto therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT kauefranke therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT pierrevansantoliveiraeugenio therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT auriceliobatistacezarjunior therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT igorvilelafaquini therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT joselaerciojuniorsilva therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT eduardovieiradecarvalhojunior therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT nivaldosalmeida therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT franciscoalfredobandeiraefarias therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT marcelomoraesvalenca therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT hildorochacirneazevedofilho therelationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT liviopereirademacedo relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT renatadecastrotavares relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT mateustorresbraga relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT lidianemouradossantos relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT glaudirdonato relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT fabioantonioserradelimajunior relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT rosannepereirademacedo relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT arlindougulinonetto relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT kauefranke relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT pierrevansantoliveiraeugenio relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT auriceliobatistacezarjunior relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT igorvilelafaquini relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT joselaerciojuniorsilva relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT eduardovieiradecarvalhojunior relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT nivaldosalmeida relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT franciscoalfredobandeiraefarias relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT marcelomoraesvalenca relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure AT hildorochacirneazevedofilho relationshipbetweenthelevelofvitamindandrupturedintracranialaneurysmsamongpatientswithhighsunexposure |