Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came f...
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MDPI AG
2017-07-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/2/3/28 |
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| author | Alain C. Juayang Joseph Peter T. Lim Ann Francis V. Bonifacio Alaica Victoria L. Lambot Sean Maybelle Millan Vic Zyrus Jeriko N. Sevilla Julien Kate T. Sy Paul John Villanueva Carmina P. Grajales Christine T. Gallega |
| author_facet | Alain C. Juayang Joseph Peter T. Lim Ann Francis V. Bonifacio Alaica Victoria L. Lambot Sean Maybelle Millan Vic Zyrus Jeriko N. Sevilla Julien Kate T. Sy Paul John Villanueva Carmina P. Grajales Christine T. Gallega |
| author_sort | Alain C. Juayang |
| collection | DOAJ |
| description | Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came from transudates and exudates (2.01%). Most of the samples were acquired from older adults (77.55%), most of whom were admitted (67.03%). Amikacin was found to be the most effective drug with a resistance rate of 7.5%, followed by piperacillin/tazobactam (8.5%) and gentamicin (13.5%). On the other hand, 26.7% of the isolates were resistant to levofloxacin. Almost 100% of the isolates were screened positive for AmpC production, which may suggest inducible resistance against expanded spectrum beta-lactamase. Furthermore, for the last three years, P. aeruginosa isolates from this area have been noted to have decreasing resistance only to aztreonam and gentamicin. Also, for five years, a mean MAR index of 0.17 was noted which indicates either proper antibiotic use or most isolates did not come from high-risk areas. Moreover, there was no significant difference in the resistance of P. aeruginosa when compared by specimen source (p = 0.662), but significant when compared by year band (p = 0.02). |
| first_indexed | 2024-04-13T08:44:07Z |
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| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-04-13T08:44:07Z |
| publishDate | 2017-07-01 |
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| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-3cbbbd455e804b34be3df9ee723fdba42022-12-22T02:53:47ZengMDPI AGTropical Medicine and Infectious Disease2414-63662017-07-01232810.3390/tropicalmed2030028tropicalmed2030028Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, PhilippinesAlain C. Juayang0Joseph Peter T. Lim1Ann Francis V. Bonifacio2Alaica Victoria L. Lambot3Sean Maybelle Millan4Vic Zyrus Jeriko N. Sevilla5Julien Kate T. Sy6Paul John Villanueva7Carmina P. Grajales8Christine T. Gallega9Clinical Laboratory, Dr. Pablo O. Torre Memorial Hospital, Bacolod City 6100, PhilippinesClinical Laboratory, Dr. Pablo O. Torre Memorial Hospital, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesMedical Technology Program, Colegio San Agustin, Bacolod City 6100, PhilippinesClinical Laboratory, Dr. Pablo O. Torre Memorial Hospital, Bacolod City 6100, PhilippinesOver five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came from transudates and exudates (2.01%). Most of the samples were acquired from older adults (77.55%), most of whom were admitted (67.03%). Amikacin was found to be the most effective drug with a resistance rate of 7.5%, followed by piperacillin/tazobactam (8.5%) and gentamicin (13.5%). On the other hand, 26.7% of the isolates were resistant to levofloxacin. Almost 100% of the isolates were screened positive for AmpC production, which may suggest inducible resistance against expanded spectrum beta-lactamase. Furthermore, for the last three years, P. aeruginosa isolates from this area have been noted to have decreasing resistance only to aztreonam and gentamicin. Also, for five years, a mean MAR index of 0.17 was noted which indicates either proper antibiotic use or most isolates did not come from high-risk areas. Moreover, there was no significant difference in the resistance of P. aeruginosa when compared by specimen source (p = 0.662), but significant when compared by year band (p = 0.02).https://www.mdpi.com/2414-6366/2/3/28antibiotic susceptibilityPseudomonas aeruginosalocal tertiary hospitalBacolod City |
| spellingShingle | Alain C. Juayang Joseph Peter T. Lim Ann Francis V. Bonifacio Alaica Victoria L. Lambot Sean Maybelle Millan Vic Zyrus Jeriko N. Sevilla Julien Kate T. Sy Paul John Villanueva Carmina P. Grajales Christine T. Gallega Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines Tropical Medicine and Infectious Disease antibiotic susceptibility Pseudomonas aeruginosa local tertiary hospital Bacolod City |
| title | Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines |
| title_full | Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines |
| title_fullStr | Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines |
| title_full_unstemmed | Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines |
| title_short | Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines |
| title_sort | five year antimicrobial susceptibility of pseudomonas aeruginosa from a local tertiary hospital in bacolod city philippines |
| topic | antibiotic susceptibility Pseudomonas aeruginosa local tertiary hospital Bacolod City |
| url | https://www.mdpi.com/2414-6366/2/3/28 |
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