Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies
With the rising worldwide obesity rates, bariatric surgeries are increasing. Although the surgery offers an effective treatment option for weight loss, the procedure causes dramatic physiological and metabolic changes. Animal models in rodents provide a valuable tool for studying the systemic effect...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1133415/full |
| _version_ | 1797852190090461184 |
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| author | Angela Mercado Anna Pham Zhijun Wang Wendong Huang Patrick Chan Hajer Ibrahim Hyma Gogineni Ying Huang Jeffrey Wang |
| author_facet | Angela Mercado Anna Pham Zhijun Wang Wendong Huang Patrick Chan Hajer Ibrahim Hyma Gogineni Ying Huang Jeffrey Wang |
| author_sort | Angela Mercado |
| collection | DOAJ |
| description | With the rising worldwide obesity rates, bariatric surgeries are increasing. Although the surgery offers an effective treatment option for weight loss, the procedure causes dramatic physiological and metabolic changes. Animal models in rodents provide a valuable tool for studying the systemic effects of the surgery. Since the surgery may significantly influence the pharmacokinetic properties of medications, animal studies should provide essential insight into mechanisms underlying changes in how the body handles the drug. This review summarizes research work in rodents regarding the impact of standard bariatric procedures on pharmacokinetics. A qualitative literature search was conducted via PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE. Studies that examined bariatric surgery’s effects on drug pharmacokinetics in rodent models were included. Clinical studies and studies not involving drug interventions were excluded. A total of 15 studies were identified and assessed in this review. These studies demonstrate the possible impact of bariatric surgery on drug absorption, distribution, metabolism, excretion, and potential mechanisms. Pharmacokinetic changes exhibited in the limited pre-clinical studies highlight a need for further investigation to fully understand the impact and mechanism of bariatric surgery on drug responses. |
| first_indexed | 2024-04-09T19:29:43Z |
| format | Article |
| id | doaj.art-3cbc3aaf9c5f4834ba1bee1a08abbf28 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:29:43Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3cbc3aaf9c5f4834ba1bee1a08abbf282023-04-05T04:35:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11334151133415Effects of bariatric surgery on drug pharmacokinetics—Preclinical studiesAngela Mercado0Anna Pham1Zhijun Wang2Wendong Huang3Patrick Chan4Hajer Ibrahim5Hyma Gogineni6Ying Huang7Jeffrey Wang8College of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesCollege of Pharmacy, Marshall B. Ketchum University, Fullerton, CA, United StatesDepartment of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, United StatesCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesKaiser Permanente, San Jose, CA, United StatesCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, United StatesWith the rising worldwide obesity rates, bariatric surgeries are increasing. Although the surgery offers an effective treatment option for weight loss, the procedure causes dramatic physiological and metabolic changes. Animal models in rodents provide a valuable tool for studying the systemic effects of the surgery. Since the surgery may significantly influence the pharmacokinetic properties of medications, animal studies should provide essential insight into mechanisms underlying changes in how the body handles the drug. This review summarizes research work in rodents regarding the impact of standard bariatric procedures on pharmacokinetics. A qualitative literature search was conducted via PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE. Studies that examined bariatric surgery’s effects on drug pharmacokinetics in rodent models were included. Clinical studies and studies not involving drug interventions were excluded. A total of 15 studies were identified and assessed in this review. These studies demonstrate the possible impact of bariatric surgery on drug absorption, distribution, metabolism, excretion, and potential mechanisms. Pharmacokinetic changes exhibited in the limited pre-clinical studies highlight a need for further investigation to fully understand the impact and mechanism of bariatric surgery on drug responses.https://www.frontiersin.org/articles/10.3389/fphar.2023.1133415/fullbariatric surgerygastric bypasspharmacokineticsobesityrodent model |
| spellingShingle | Angela Mercado Anna Pham Zhijun Wang Wendong Huang Patrick Chan Hajer Ibrahim Hyma Gogineni Ying Huang Jeffrey Wang Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies Frontiers in Pharmacology bariatric surgery gastric bypass pharmacokinetics obesity rodent model |
| title | Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies |
| title_full | Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies |
| title_fullStr | Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies |
| title_full_unstemmed | Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies |
| title_short | Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies |
| title_sort | effects of bariatric surgery on drug pharmacokinetics preclinical studies |
| topic | bariatric surgery gastric bypass pharmacokinetics obesity rodent model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1133415/full |
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