No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study
Background: Although previous studies found that inflammatory bowel disease (IBD) and diverticular disease (DD) usually co-exist clinically, studies examining the relationship are spare.Aim: Our study aspires to investigate the causal correlation between the IBD [including ulcerative colitis (UC) an...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1334473/full |
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| author | Ailikamu Aierken Falide Atabieke Munire Aierken Jian Li Yu Xia Yierzhati Aizezi Shui-Xue Li |
| author_facet | Ailikamu Aierken Falide Atabieke Munire Aierken Jian Li Yu Xia Yierzhati Aizezi Shui-Xue Li |
| author_sort | Ailikamu Aierken |
| collection | DOAJ |
| description | Background: Although previous studies found that inflammatory bowel disease (IBD) and diverticular disease (DD) usually co-exist clinically, studies examining the relationship are spare.Aim: Our study aspires to investigate the causal correlation between the IBD [including ulcerative colitis (UC) and Crohn’s disease (CD)] and DD using the Mendelian randomization (MR) analysis.Methods: We conducted a two-sample bidirectional MR analysis using publicly available genome-wide association studies (GWAS) summary data. The single nucleotide polymorphism (SNP) data associated with DD and IBD were obtained from the Finnish Biobank and UK Biobank, respectively. Through secondary data analysis of all GWAS summary data, we systematically screened genetic instrumental variables. To address the impact of horizontal pleiotropy, several methods were employed, including the inverse variance-weighted method (IVW), maximum likelihood method, Egger regression method, weighted median method, and simple median method. These approaches aimed to detect and correct for the potential bias caused by horizontal pleiotropy.Results: Genetically predicted DD did not have a causal effect on IBD (OR 1.06, 95% CI 0.98–1.17, p = 0.15), and had no causal effect on UC (OR 1.10, 95% CI 0.94–1.20, p = 0.36) and CD (OR 1.03, 95% CI 0.92–1.16, p = 0.62) either. Furthermore, in the reverse MR analysis, we did not observe any significant causal effect of IBD on DD. Results of complementary methods showed consistent results with those of the IVW method.Conclusion: This study’s findings do not provide evidence for a causal relationship between IBD and DD, which contradicts the majority of observational studies. |
| first_indexed | 2024-03-08T02:02:35Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-08T02:02:35Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-3cbd7ef4ed04422999c86fb2cdee95782024-02-14T04:59:37ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-02-011510.3389/fgene.2024.13344731334473No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization studyAilikamu Aierken0Falide Atabieke1Munire Aierken2Jian Li3Yu Xia4Yierzhati Aizezi5Shui-Xue Li6Graduate School of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Disinfection and Vector-Borne Pathogen Control, Urumqi City Center for Disease Prevention and Control, Urumqi, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaCenter of Critical Care Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of General Surgery, Children’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaBackground: Although previous studies found that inflammatory bowel disease (IBD) and diverticular disease (DD) usually co-exist clinically, studies examining the relationship are spare.Aim: Our study aspires to investigate the causal correlation between the IBD [including ulcerative colitis (UC) and Crohn’s disease (CD)] and DD using the Mendelian randomization (MR) analysis.Methods: We conducted a two-sample bidirectional MR analysis using publicly available genome-wide association studies (GWAS) summary data. The single nucleotide polymorphism (SNP) data associated with DD and IBD were obtained from the Finnish Biobank and UK Biobank, respectively. Through secondary data analysis of all GWAS summary data, we systematically screened genetic instrumental variables. To address the impact of horizontal pleiotropy, several methods were employed, including the inverse variance-weighted method (IVW), maximum likelihood method, Egger regression method, weighted median method, and simple median method. These approaches aimed to detect and correct for the potential bias caused by horizontal pleiotropy.Results: Genetically predicted DD did not have a causal effect on IBD (OR 1.06, 95% CI 0.98–1.17, p = 0.15), and had no causal effect on UC (OR 1.10, 95% CI 0.94–1.20, p = 0.36) and CD (OR 1.03, 95% CI 0.92–1.16, p = 0.62) either. Furthermore, in the reverse MR analysis, we did not observe any significant causal effect of IBD on DD. Results of complementary methods showed consistent results with those of the IVW method.Conclusion: This study’s findings do not provide evidence for a causal relationship between IBD and DD, which contradicts the majority of observational studies.https://www.frontiersin.org/articles/10.3389/fgene.2024.1334473/fullinflammatory bowel diseasediverticular diseaseMendelian randomizationcausalityCrohn’s diseaseulcerative colitis |
| spellingShingle | Ailikamu Aierken Falide Atabieke Munire Aierken Jian Li Yu Xia Yierzhati Aizezi Shui-Xue Li No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study Frontiers in Genetics inflammatory bowel disease diverticular disease Mendelian randomization causality Crohn’s disease ulcerative colitis |
| title | No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study |
| title_full | No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study |
| title_fullStr | No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study |
| title_full_unstemmed | No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study |
| title_short | No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study |
| title_sort | no bidirectional relationship between inflammatory bowel disease and diverticular disease a genetic correlation and mendelian randomization study |
| topic | inflammatory bowel disease diverticular disease Mendelian randomization causality Crohn’s disease ulcerative colitis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1334473/full |
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