A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci
Analysis of X-chromosome short tandem repeats (STRs) is very helpful in deficiency paternity testing. Here, we reported a case of kinship analysis that showed a potentially erroneous inclusion of paternal sisters between two women. The two women shared alleles at 18 X-chromosomal STR loci spanned fr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Forensic Science and Medicine |
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| Online Access: | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=2;spage=115;epage=118;aulast= |
| _version_ | 1818958138009714688 |
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| author | Qiu-Ling Liu Li Xue Hu Zhao De-Jian Lu |
| author_facet | Qiu-Ling Liu Li Xue Hu Zhao De-Jian Lu |
| author_sort | Qiu-Ling Liu |
| collection | DOAJ |
| description | Analysis of X-chromosome short tandem repeats (STRs) is very helpful in deficiency paternity testing. Here, we reported a case of kinship analysis that showed a potentially erroneous inclusion of paternal sisters between two women. The two women shared alleles at 18 X-chromosomal STR loci spanned from 14.76cM (DXS6807) to 184.19cM (DXS7423). When their relatives were not available for testing, biostatistical analysis for the 18 X-chromosomal STR loci and 24 autosomal STR loci revealed the most possible relationship between the two women was paternal sisters. However, when the father of one woman was available, the other father-daughter possibility was excluded. In the end, the likelihood ratio of STR marker and mitochondrial DNA (mtDNA) sequences confirmed the two women were maternal sisters. This case emphasizes a cautionary interpretation of X chromosomal marker in deficiency paternity cases with female offspring. Even though large parts of the X-chromosome haplotypes shared by two females, additional relatives and extended DNA typing (such as mtDNA) may be needed further to ascertain whether they are paternal or maternal sisters. |
| first_indexed | 2024-12-20T11:20:58Z |
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| id | doaj.art-3cc08c6779ff49aabaafeb0b11a5a456 |
| institution | Directory Open Access Journal |
| issn | 2349-5014 |
| language | English |
| last_indexed | 2024-12-20T11:20:58Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Journal of Forensic Science and Medicine |
| spelling | doaj.art-3cc08c6779ff49aabaafeb0b11a5a4562022-12-21T19:42:31ZengWolters Kluwer Medknow PublicationsJournal of Forensic Science and Medicine2349-50142016-01-012211511810.4103/2349-5014.184194A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat LociQiu-Ling LiuLi XueHu ZhaoDe-Jian LuAnalysis of X-chromosome short tandem repeats (STRs) is very helpful in deficiency paternity testing. Here, we reported a case of kinship analysis that showed a potentially erroneous inclusion of paternal sisters between two women. The two women shared alleles at 18 X-chromosomal STR loci spanned from 14.76cM (DXS6807) to 184.19cM (DXS7423). When their relatives were not available for testing, biostatistical analysis for the 18 X-chromosomal STR loci and 24 autosomal STR loci revealed the most possible relationship between the two women was paternal sisters. However, when the father of one woman was available, the other father-daughter possibility was excluded. In the end, the likelihood ratio of STR marker and mitochondrial DNA (mtDNA) sequences confirmed the two women were maternal sisters. This case emphasizes a cautionary interpretation of X chromosomal marker in deficiency paternity cases with female offspring. Even though large parts of the X-chromosome haplotypes shared by two females, additional relatives and extended DNA typing (such as mtDNA) may be needed further to ascertain whether they are paternal or maternal sisters.http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=2;spage=115;epage=118;aulast=Haplotypekinship testingrecombinationX-chromosome short tandem repeat |
| spellingShingle | Qiu-Ling Liu Li Xue Hu Zhao De-Jian Lu A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci Journal of Forensic Science and Medicine Haplotype kinship testing recombination X-chromosome short tandem repeat |
| title | A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci |
| title_full | A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci |
| title_fullStr | A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci |
| title_full_unstemmed | A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci |
| title_short | A Case of Maternal Half-sisters Sharing Alleles at 18 X-chromosomal Short Tandem Repeat Loci |
| title_sort | case of maternal half sisters sharing alleles at 18 x chromosomal short tandem repeat loci |
| topic | Haplotype kinship testing recombination X-chromosome short tandem repeat |
| url | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=2;spage=115;epage=118;aulast= |
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