A γ-Secretase Inhibitor Attenuates Cell Cycle Progression and Invasion in Human Oral Squamous Cell Carcinoma: An In Vitro Study

A γ-Secretase Inhibitor Attenuates Cell Cycle Progression and Invasion in Human Oral Squamous Cell Carcinoma: An In Vitro Study

Notch signaling is associated with many human malignancies, including oral squamous cell carcinoma (OSCC). However, the exact function of Notch signaling in OSCC remains unclear. Here, we investigated the effect of Notch signaling inhibition using a γ-secretase inhibitor (DAPT) on OSCC behaviours in...

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Bibliographic Details
Main Authors: Sarai Pongjantarasatian, Nunthawan Nowwarote, Varumporn Rotchanakitamnuai, Watcharee Srirodjanakul, Ritmongkol Saehun, Kajohnkiart Janebodin, Jeeranan Manokawinchoke, Benjamin P. J. Fournier, Thanaphum Osathanon
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
oral squamous cell carcinoma
Notch
g-secretase
cell cycle
Notch pathway
Online Access:https://www.mdpi.com/1422-0067/23/16/8869

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