Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities
The current research is concerned with the synthesis of magnesium oxide (MgO) nanoparticles (NPs) from <i>Abrus precatorius</i> L. bark extract via the green chemistry method. The synthesized MgO NPs was confirmed by using several characterization methods like XRD, FTIR, SEM, TEM, and UV...
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MDPI AG
2023-02-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/3/302 |
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| author | Saheb Ali Kattakgoundar Govindaraj Sudha Natesan Thirumalaivasan Maqusood Ahamed Saravanan Pandiaraj Vijayarangan Devi Rajeswari Yamini Vinayagam Muthu Thiruvengadam Rajakumar Govindasamy |
| author_facet | Saheb Ali Kattakgoundar Govindaraj Sudha Natesan Thirumalaivasan Maqusood Ahamed Saravanan Pandiaraj Vijayarangan Devi Rajeswari Yamini Vinayagam Muthu Thiruvengadam Rajakumar Govindasamy |
| author_sort | Saheb Ali |
| collection | DOAJ |
| description | The current research is concerned with the synthesis of magnesium oxide (MgO) nanoparticles (NPs) from <i>Abrus precatorius</i> L. bark extract via the green chemistry method. The synthesized MgO NPs was confirmed by using several characterization methods like XRD, FTIR, SEM, TEM, and UV-visible analysis. The synthesized MgO NPs displayed a small particle size along with a specific surface area. <i>Abrus precatorius</i> bark synthesized MgO NPs with a higher ratio of dye degradation, and antioxidant activity showed a higher percentage of free radical scavenging in synthesized MgO NPs. Zebrafish embryos were used as a model organism to assess the toxicity of the obtained MgO nanoparticles, and the results concluded that the MgO NPs were nontoxic. In addition, the anticancer properties of MgO nanoparticles were analyzed by using a human melanoma cancer cell line (A375) via MTT, XTT, NRU, and LDH assessment. MgO NPs treated a human melanoma cancer cell line and resulted in apoptosis and necrosis based on the concentration, which was confirmed through a genotoxicity assay. Moreover, the molecular mechanisms in necrosis and apoptosis were conferred to depict the association of magnesium oxide nanoparticles with the human melanoma cancer cell line. The current study on MgO NPs showed a broad-scope understanding of the use of these nanoparticles as a medicinal drug for melanoma cancer via its physiological mechanism and also a novel route to obtain MgO NPs by using the green chemistry method. |
| first_indexed | 2024-03-11T06:55:19Z |
| format | Article |
| id | doaj.art-3cc33bb19fb447d99977cab1d5354f6e |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T06:55:19Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-3cc33bb19fb447d99977cab1d5354f6e2023-11-17T09:39:21ZengMDPI AGBioengineering2306-53542023-02-0110330210.3390/bioengineering10030302Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity ActivitiesSaheb Ali0Kattakgoundar Govindaraj Sudha1Natesan Thirumalaivasan2Maqusood Ahamed3Saravanan Pandiaraj4Vijayarangan Devi Rajeswari5Yamini Vinayagam6Muthu Thiruvengadam7Rajakumar Govindasamy8Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, Tamil Nadu, IndiaDepartment of Biotechnology, K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode 637215, Tamil Nadu, IndiaDepartment of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, Tamil Nadu, IndiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Self-Development Skills, CFY Deanship, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biomedical Sciences, School of Bioscience and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Bioscience and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaDepartment of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, Tamil Nadu, IndiaThe current research is concerned with the synthesis of magnesium oxide (MgO) nanoparticles (NPs) from <i>Abrus precatorius</i> L. bark extract via the green chemistry method. The synthesized MgO NPs was confirmed by using several characterization methods like XRD, FTIR, SEM, TEM, and UV-visible analysis. The synthesized MgO NPs displayed a small particle size along with a specific surface area. <i>Abrus precatorius</i> bark synthesized MgO NPs with a higher ratio of dye degradation, and antioxidant activity showed a higher percentage of free radical scavenging in synthesized MgO NPs. Zebrafish embryos were used as a model organism to assess the toxicity of the obtained MgO nanoparticles, and the results concluded that the MgO NPs were nontoxic. In addition, the anticancer properties of MgO nanoparticles were analyzed by using a human melanoma cancer cell line (A375) via MTT, XTT, NRU, and LDH assessment. MgO NPs treated a human melanoma cancer cell line and resulted in apoptosis and necrosis based on the concentration, which was confirmed through a genotoxicity assay. Moreover, the molecular mechanisms in necrosis and apoptosis were conferred to depict the association of magnesium oxide nanoparticles with the human melanoma cancer cell line. The current study on MgO NPs showed a broad-scope understanding of the use of these nanoparticles as a medicinal drug for melanoma cancer via its physiological mechanism and also a novel route to obtain MgO NPs by using the green chemistry method.https://www.mdpi.com/2306-5354/10/3/302<i>Abrus precatorius</i>MgO nanoparticlesbiomedical engineeringcytotoxicitygenotoxicityprotein signaling pathways |
| spellingShingle | Saheb Ali Kattakgoundar Govindaraj Sudha Natesan Thirumalaivasan Maqusood Ahamed Saravanan Pandiaraj Vijayarangan Devi Rajeswari Yamini Vinayagam Muthu Thiruvengadam Rajakumar Govindasamy Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities Bioengineering <i>Abrus precatorius</i> MgO nanoparticles biomedical engineering cytotoxicity genotoxicity protein signaling pathways |
| title | Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities |
| title_full | Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities |
| title_fullStr | Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities |
| title_full_unstemmed | Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities |
| title_short | Green Synthesis of Magnesium Oxide Nanoparticles by Using <i>Abrus precatorius</i> Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities |
| title_sort | green synthesis of magnesium oxide nanoparticles by using i abrus precatorius i bark extract and their photocatalytic antioxidant antibacterial and cytotoxicity activities |
| topic | <i>Abrus precatorius</i> MgO nanoparticles biomedical engineering cytotoxicity genotoxicity protein signaling pathways |
| url | https://www.mdpi.com/2306-5354/10/3/302 |
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