Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study
Introduction: Serum Retinol Binding Protein 4 (RBP4), an adipokine that transports vitamin A from the liver to other tissues, is reported to be elevated in hypertensive subjects. Positive correlation between RBP4 and cardiovascular risk factors has been noted in a few studies. Aim: To evaluate seru...
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JCDR Research and Publications Private Limited
2022-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17043/57683_CE(AD)_F[SH]_PF1(PS_OM)_PN(SS).pdf |
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| author | Suman Tripathy Nirupama Devi Devi Prasad Pradhan Rasmita Kumari Padhy Sucheta Panda Sudipta Onkar |
| author_facet | Suman Tripathy Nirupama Devi Devi Prasad Pradhan Rasmita Kumari Padhy Sucheta Panda Sudipta Onkar |
| author_sort | Suman Tripathy |
| collection | DOAJ |
| description | Introduction: Serum Retinol Binding Protein 4 (RBP4), an adipokine that transports vitamin A from the liver to other tissues, is reported to be elevated in hypertensive subjects. Positive correlation between RBP4 and cardiovascular risk factors has been noted in a few studies.
Aim: To evaluate serum RBP4 levels in newly diagnosed primary
hypertensive cases and non hypertensive controls and to correlate serum RBP4 levels with lipid profile.
Materials and Methods: This case-control study was conducted at the Department of Biochemistry in collaboration with the Department of Medicine, from August 2019 to June 2020 in MKCG Medical College and Hospital, Berhampur, Odisha, India. A total of 51 newly diagnosed primary hypertensive patients and 51 healthy age and sex-matched
individuals between the ages of 18-50 years were enrolled in the study. Systolic and Diastolic Blood Pressure (SBP and DBP) were measured in both cases and controls. Serum RBP4 was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and other biochemical parameters were measured by TBA120FR autoanalyser. Statistical analysis of the data was
done by using Statistical Package for Social Sciences (SPSS) software, version 22.0.
Results: The mean age for controls was 36.98±8.7 years and that in cases was 39.00±8.4 years. Proportion of males was higher (56.8%) than females (43.2%). The mean SBP in the case group was significantly higher as compared to the control group. The cases had a higher level of serum RBP4 (31.82 mg/L) compared to the control groups (15.5 mg/L) RBP4 (p<0.001). The cases had a higher level of mean serum triglyceride (196.20±67.81 mg/dL) and lower level of mean serum High-Density Lipoprotein cholesterol (HDLc) (37.53±11.90 mg/dL) as compared to the
control groups which had a mean triglyceride of 104.25±39.89 mg/dL and HDLc of 57.18±10.73 mg/dL (p<0.001). The serum RBP4 level positively correlated with SBP (r=0.644, p<0.001), DBP (r=0.444, p<0.001), serum triglycerides (r=0.649, p<0.001), and negatively correlated with HDLc (r=-0.313, p=0.025)
Conclusion: A high serum RBP4 level was found in the newly
diagnosed hypertensive cases as compared to normotensive
controls. A significant positive correlation was observed between
RBP4 with SBP and DBP along with triglyceride levels. A significant
negative correlation was observed between RBP4 with HDLc. |
| first_indexed | 2024-04-10T07:51:50Z |
| format | Article |
| id | doaj.art-3cc40af2a34f4a629a6e36c6c8900574 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T07:51:50Z |
| publishDate | 2022-10-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3cc40af2a34f4a629a6e36c6c89005742023-02-23T09:51:20ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-10-011610BC18BC2110.7860/JCDR/2022/57683.17043Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control StudySuman Tripathy0Nirupama Devi1Devi Prasad Pradhan2Rasmita Kumari Padhy3Sucheta Panda4Sudipta Onkar5Senior Resident, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Professor and Head, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Assistant Professor, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Associate Professor, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Assistant Professor, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Postgraduate Student, Department of Biochemistry, MKCG Medical College, Berhampur, Odisha, India.Introduction: Serum Retinol Binding Protein 4 (RBP4), an adipokine that transports vitamin A from the liver to other tissues, is reported to be elevated in hypertensive subjects. Positive correlation between RBP4 and cardiovascular risk factors has been noted in a few studies. Aim: To evaluate serum RBP4 levels in newly diagnosed primary hypertensive cases and non hypertensive controls and to correlate serum RBP4 levels with lipid profile. Materials and Methods: This case-control study was conducted at the Department of Biochemistry in collaboration with the Department of Medicine, from August 2019 to June 2020 in MKCG Medical College and Hospital, Berhampur, Odisha, India. A total of 51 newly diagnosed primary hypertensive patients and 51 healthy age and sex-matched individuals between the ages of 18-50 years were enrolled in the study. Systolic and Diastolic Blood Pressure (SBP and DBP) were measured in both cases and controls. Serum RBP4 was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and other biochemical parameters were measured by TBA120FR autoanalyser. Statistical analysis of the data was done by using Statistical Package for Social Sciences (SPSS) software, version 22.0. Results: The mean age for controls was 36.98±8.7 years and that in cases was 39.00±8.4 years. Proportion of males was higher (56.8%) than females (43.2%). The mean SBP in the case group was significantly higher as compared to the control group. The cases had a higher level of serum RBP4 (31.82 mg/L) compared to the control groups (15.5 mg/L) RBP4 (p<0.001). The cases had a higher level of mean serum triglyceride (196.20±67.81 mg/dL) and lower level of mean serum High-Density Lipoprotein cholesterol (HDLc) (37.53±11.90 mg/dL) as compared to the control groups which had a mean triglyceride of 104.25±39.89 mg/dL and HDLc of 57.18±10.73 mg/dL (p<0.001). The serum RBP4 level positively correlated with SBP (r=0.644, p<0.001), DBP (r=0.444, p<0.001), serum triglycerides (r=0.649, p<0.001), and negatively correlated with HDLc (r=-0.313, p=0.025) Conclusion: A high serum RBP4 level was found in the newly diagnosed hypertensive cases as compared to normotensive controls. A significant positive correlation was observed between RBP4 with SBP and DBP along with triglyceride levels. A significant negative correlation was observed between RBP4 with HDLc.https://jcdr.net/articles/PDF/17043/57683_CE(AD)_F[SH]_PF1(PS_OM)_PN(SS).pdfadipokinecardiovascular risklipid profile |
| spellingShingle | Suman Tripathy Nirupama Devi Devi Prasad Pradhan Rasmita Kumari Padhy Sucheta Panda Sudipta Onkar Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study Journal of Clinical and Diagnostic Research adipokine cardiovascular risk lipid profile |
| title | Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study |
| title_full | Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study |
| title_fullStr | Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study |
| title_full_unstemmed | Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study |
| title_short | Role of Serum Retinol Binding Protein 4 (RBP4) Concentration in Patients with Primary Hypertension: A Case-control Study |
| title_sort | role of serum retinol binding protein 4 rbp4 concentration in patients with primary hypertension a case control study |
| topic | adipokine cardiovascular risk lipid profile |
| url | https://jcdr.net/articles/PDF/17043/57683_CE(AD)_F[SH]_PF1(PS_OM)_PN(SS).pdf |
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