Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy

Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy

Hypertensive nephropathy (HN), mainly caused by chronic hypertension, is one of the major causes of end-stage renal disease. However, the pathogenesis of HN remains unclarified, and there is an urgent need for improved treatments. Gene expression profiles for HN and normal tissue were obtained from...

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Bibliographic Details
Main Authors: Shilong You, Jiaqi Xu, Boquan Wu, Shaojun Wu, Ying Zhang, Yingxian Sun, Naijin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Genetics
Subjects:
hypertensive nephropathy (HN)
weighted gene co-expression network analysis (WGCNA)
differentially expressed genes (DEGs)
pathogenesis
key gene
POLR2I
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.698570/full

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