Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin
Background and Objective: Cardiovascular disorders are amongst the most prevalent complications of diabetes mellitus in long term. Since vascular responsiveness to vasoactive agents changes in diabetes with time, this experimental study was conducted to evaluate time-dependent changes in the respons...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2006-03-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-601-en.html |
| _version_ | 1818719746588147712 |
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| author | M Roghani T Baluchnejadmojarad |
| author_facet | M Roghani T Baluchnejadmojarad |
| author_sort | M Roghani |
| collection | DOAJ |
| description | Background and Objective: Cardiovascular disorders are amongst the most prevalent complications of diabetes mellitus in long term. Since vascular responsiveness to vasoactive agents changes in diabetes with time, this experimental study was conducted to evaluate time-dependent changes in the responsiveness of thoracic aorta of diabetic rats to the flavonoid quercetin.
Methods: For this purpose, male wistar rats were divided into control and experimental groups. For induction of diabetes, streptozotocin (i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd, 4th, and 8th weeks after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and quercetin-induced vasorelaxation were measured at 4th and 8th weeks.
Results: The results showed that after 4 and 8 weeks, quercetin (0.1 μM-1 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl and/or NA from both control and diabetic groups. Furthermore, this vasorelaxation was significantly attenuated in diabetic group eight weeks after the study in comparison with data at fourth week.
Conclusion: It can be concluded that the vasorelaxant effect of this flavonoid is attenuated in diabetes mellitus with time. |
| first_indexed | 2024-12-17T20:11:51Z |
| format | Article |
| id | doaj.art-3cc6822631d4424b8ac2521846d2e932 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T20:11:51Z |
| publishDate | 2006-03-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-3cc6822631d4424b8ac2521846d2e9322022-12-21T21:34:13ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582006-03-015174247Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetinM Roghani0T Baluchnejadmojarad1 1- Department of Physiology, School of Medicine, Shahed University and Medicinal plant research center, Tehran 2- Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran Background and Objective: Cardiovascular disorders are amongst the most prevalent complications of diabetes mellitus in long term. Since vascular responsiveness to vasoactive agents changes in diabetes with time, this experimental study was conducted to evaluate time-dependent changes in the responsiveness of thoracic aorta of diabetic rats to the flavonoid quercetin. Methods: For this purpose, male wistar rats were divided into control and experimental groups. For induction of diabetes, streptozotocin (i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd, 4th, and 8th weeks after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and quercetin-induced vasorelaxation were measured at 4th and 8th weeks. Results: The results showed that after 4 and 8 weeks, quercetin (0.1 μM-1 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl and/or NA from both control and diabetic groups. Furthermore, this vasorelaxation was significantly attenuated in diabetic group eight weeks after the study in comparison with data at fourth week. Conclusion: It can be concluded that the vasorelaxant effect of this flavonoid is attenuated in diabetes mellitus with time.http://jmp.ir/article-1-601-en.htmlquercetinthoracic aortadiabetes mellitusrat |
| spellingShingle | M Roghani T Baluchnejadmojarad Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin Journal of Medicinal Plants quercetin thoracic aorta diabetes mellitus rat |
| title | Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| title_full | Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| title_fullStr | Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| title_full_unstemmed | Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| title_short | Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| title_sort | time dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin |
| topic | quercetin thoracic aorta diabetes mellitus rat |
| url | http://jmp.ir/article-1-601-en.html |
| work_keys_str_mv | AT mroghani timedependentchangesinresponsivenessofthoracicaortaofdiabeticratstoquercetin AT tbaluchnejadmojarad timedependentchangesinresponsivenessofthoracicaortaofdiabeticratstoquercetin |