Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan
The delayed treatment of pediatric periorbital cellulitis may have severe consequences. In addition, the antibiotic efficacy against causative bacteria may change over time, and it is important to understand the appropriate antibiotic options for effective treatment in pediatric patients. We compare...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/10/1288 |
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| author | En-Jie Shih Jui-Kuang Chen Pei-Jhen Tsai Muh-Chiou Lin Youn-Shen Bee |
| author_facet | En-Jie Shih Jui-Kuang Chen Pei-Jhen Tsai Muh-Chiou Lin Youn-Shen Bee |
| author_sort | En-Jie Shih |
| collection | DOAJ |
| description | The delayed treatment of pediatric periorbital cellulitis may have severe consequences. In addition, the antibiotic efficacy against causative bacteria may change over time, and it is important to understand the appropriate antibiotic options for effective treatment in pediatric patients. We compared the changes in cultured bacteria and drug susceptibility tests between two decades, 2010–2019 and 2000–2009, to establish antibiotics for empirical use. The patient characteristics, etiologies, culture sites, and isolated bacteria, and the antibiotic susceptibility tests of the admitted pediatric patients (<i>n</i> = 207) diagnosed with preseptal and orbital cellulitis during 2000 to 2019, were recorded. Insect/animal bites (<i>p</i> = 0.084) showed an increasing trend, and sinusitis (<i>p</i> = 0.016) showed a significant decrease in the past decades. The most common bacteria were <i>Staphylococcus aureus</i>, and methicillin-resistant <i>S. aureus</i> (MRSA) infections increased in recent decades (<i>p</i> = 0.01). Moreover, we found that vancomycin was ideal for MRSA infections. The decreasing efficacy of oxacillin correlates with the increasing proportion of MRSA in pediatric periorbital cellulitis. Our study thus offers antibiotic choices against the most common isolates that can be administered before culture results are available. |
| first_indexed | 2024-03-09T20:50:28Z |
| format | Article |
| id | doaj.art-3cc8a45cbaff4d14818abe7ca504bd72 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:50:28Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-3cc8a45cbaff4d14818abe7ca504bd722023-11-23T22:33:59ZengMDPI AGAntibiotics2079-63822022-09-011110128810.3390/antibiotics11101288Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from TaiwanEn-Jie Shih0Jui-Kuang Chen1Pei-Jhen Tsai2Muh-Chiou Lin3Youn-Shen Bee4Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanDivision of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanDepartment of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanDepartment of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanDepartment of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanThe delayed treatment of pediatric periorbital cellulitis may have severe consequences. In addition, the antibiotic efficacy against causative bacteria may change over time, and it is important to understand the appropriate antibiotic options for effective treatment in pediatric patients. We compared the changes in cultured bacteria and drug susceptibility tests between two decades, 2010–2019 and 2000–2009, to establish antibiotics for empirical use. The patient characteristics, etiologies, culture sites, and isolated bacteria, and the antibiotic susceptibility tests of the admitted pediatric patients (<i>n</i> = 207) diagnosed with preseptal and orbital cellulitis during 2000 to 2019, were recorded. Insect/animal bites (<i>p</i> = 0.084) showed an increasing trend, and sinusitis (<i>p</i> = 0.016) showed a significant decrease in the past decades. The most common bacteria were <i>Staphylococcus aureus</i>, and methicillin-resistant <i>S. aureus</i> (MRSA) infections increased in recent decades (<i>p</i> = 0.01). Moreover, we found that vancomycin was ideal for MRSA infections. The decreasing efficacy of oxacillin correlates with the increasing proportion of MRSA in pediatric periorbital cellulitis. Our study thus offers antibiotic choices against the most common isolates that can be administered before culture results are available.https://www.mdpi.com/2079-6382/11/10/1288pediatric periorbital cellulitisetiologiesbacteriadrug susceptibility testsantibiotics |
| spellingShingle | En-Jie Shih Jui-Kuang Chen Pei-Jhen Tsai Muh-Chiou Lin Youn-Shen Bee Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan Antibiotics pediatric periorbital cellulitis etiologies bacteria drug susceptibility tests antibiotics |
| title | Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan |
| title_full | Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan |
| title_fullStr | Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan |
| title_full_unstemmed | Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan |
| title_short | Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan |
| title_sort | antibiotic choices for pediatric periorbital cellulitis a 20 year retrospective study from taiwan |
| topic | pediatric periorbital cellulitis etiologies bacteria drug susceptibility tests antibiotics |
| url | https://www.mdpi.com/2079-6382/11/10/1288 |
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