mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the a...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2020-02-01
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| Series: | mSphere |
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| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00954-19 |
| _version_ | 1818836619970478080 |
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| author | Mark C. Walker |
| author_facet | Mark C. Walker |
| author_sort | Mark C. Walker |
| collection | DOAJ |
| description | ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis. |
| first_indexed | 2024-12-19T03:09:30Z |
| format | Article |
| id | doaj.art-3cc8da35460247219436b19bd5ec1fb6 |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-12-19T03:09:30Z |
| publishDate | 2020-02-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-3cc8da35460247219436b19bd5ec1fb62022-12-21T20:38:03ZengAmerican Society for MicrobiologymSphere2379-50422020-02-015110.1128/mSphere.00954-19mSphere of Influence: Synthetic Biology of Natural Product BiosynthesisMark C. Walker0Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, USAABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis.https://journals.asm.org/doi/10.1128/mSphere.00954-19biosynthesismetabolic engineeringnatural product |
| spellingShingle | Mark C. Walker mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis mSphere biosynthesis metabolic engineering natural product |
| title | mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis |
| title_full | mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis |
| title_fullStr | mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis |
| title_full_unstemmed | mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis |
| title_short | mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis |
| title_sort | msphere of influence synthetic biology of natural product biosynthesis |
| topic | biosynthesis metabolic engineering natural product |
| url | https://journals.asm.org/doi/10.1128/mSphere.00954-19 |
| work_keys_str_mv | AT markcwalker msphereofinfluencesyntheticbiologyofnaturalproductbiosynthesis |