Intravenous AAV9 Efficiently Transduces Myenteric Neurons in Neonate and Juvenile Mice

Intravenous AAV9 Efficiently Transduces Myenteric Neurons in Neonate and Juvenile Mice

Our recent discovery that adeno-associated virus type 9 (AAV9) can cross the blood brain barrier holds promise for the treatment of global neurological disease. Early studies with AAV9 gene therapy focused on transduction within the brain and spinal cord, but intravenous infusion results in widespr...

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Bibliographic Details
Main Authors:	Sara Elizabeth Gombash, Christopher J Cowley, Julie A Fitzgerald, Jodie CE Hall, Christian eMueller, Fedias L Christofi, Kevin David Foust
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-10-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	Enteric Nervous System Gene Therapy Myenteric Plexus adeno-associated virus enteric glia enteric neuropathy
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00081/full

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