Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases
Retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration are the main clinical blinding eye diseases with complex etiology and irreversible damage to vision. CX3CR1 is a specific receptor of the chemokine CX3CL1. Both of them participate in various physiologica...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-08-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2021/8/202108010.pdf |
| _version_ | 1819152761768378368 |
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| author | Yu-Lin Qi Xi-Yu Jia He-Jiang Ye |
| author_facet | Yu-Lin Qi Xi-Yu Jia He-Jiang Ye |
| author_sort | Yu-Lin Qi |
| collection | DOAJ |
| description | Retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration are the main clinical blinding eye diseases with complex etiology and irreversible damage to vision. CX3CR1 is a specific receptor of the chemokine CX3CL1. Both of them participate in various physiological functions and pathological changes of the whole body through regulating the immune system of the body. In recent years, studies have pointed out that CX3CR1 regulates the activity and function of retinal microglia, which play an important role in the process of retinal degenerative diseases. In this paper, the structure and function of the chemokine receptor CX3CR1 and the role of microglia in retinal degenerative diseases were reviewed, so as to provide ideas and directions for future research and treatment of such diseases. |
| first_indexed | 2024-12-22T14:54:26Z |
| format | Article |
| id | doaj.art-3cca96355394491d8cc96444e2442a41 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-22T14:54:26Z |
| publishDate | 2021-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-3cca96355394491d8cc96444e2442a412022-12-21T18:22:15ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232021-08-012181363136710.3980/j.issn.1672-5123.2021.8.10202108010Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseasesYu-Lin Qi0Xi-Yu Jia1He-Jiang Ye2Chengdu University of TCM, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Affiliated Hospital of Chengdu University of TCM, Chengdu 610075, Sichuan Province, ChinaChengdu University of TCM, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Affiliated Hospital of Chengdu University of TCM, Chengdu 610075, Sichuan Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Chengdu University of TCM, Chengdu 610075, Sichuan Province, ChinaRetinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration are the main clinical blinding eye diseases with complex etiology and irreversible damage to vision. CX3CR1 is a specific receptor of the chemokine CX3CL1. Both of them participate in various physiological functions and pathological changes of the whole body through regulating the immune system of the body. In recent years, studies have pointed out that CX3CR1 regulates the activity and function of retinal microglia, which play an important role in the process of retinal degenerative diseases. In this paper, the structure and function of the chemokine receptor CX3CR1 and the role of microglia in retinal degenerative diseases were reviewed, so as to provide ideas and directions for future research and treatment of such diseases.http://ies.ijo.cn/cn_publish/2021/8/202108010.pdfcx3cr1cx3cl1microgliaretinal degenerative diseases |
| spellingShingle | Yu-Lin Qi Xi-Yu Jia He-Jiang Ye Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases Guoji Yanke Zazhi cx3cr1 cx3cl1 microglia retinal degenerative diseases |
| title | Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases |
| title_full | Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases |
| title_fullStr | Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases |
| title_full_unstemmed | Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases |
| title_short | Research advances of chemokine receptor CX3CR1 and microglia in retinal degenerative diseases |
| title_sort | research advances of chemokine receptor cx3cr1 and microglia in retinal degenerative diseases |
| topic | cx3cr1 cx3cl1 microglia retinal degenerative diseases |
| url | http://ies.ijo.cn/cn_publish/2021/8/202108010.pdf |
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