Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/3/2424 |
| _version_ | 1797624386798223360 |
|---|---|
| author | Munishwar Nath Gupta Vladimir N. Uversky |
| author_facet | Munishwar Nath Gupta Vladimir N. Uversky |
| author_sort | Munishwar Nath Gupta |
| collection | DOAJ |
| description | Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed. |
| first_indexed | 2024-03-11T09:41:40Z |
| format | Article |
| id | doaj.art-3ccb3998648a49f2b92f3cd18d9c6a30 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3ccb3998648a49f2b92f3cd18d9c6a302023-11-16T16:57:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243242410.3390/ijms24032424Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of ProteinsMunishwar Nath Gupta0Vladimir N. Uversky1Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, IndiaDepartment of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USATransitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed.https://www.mdpi.com/1422-0067/24/3/2424baroenzymologycryoenzymologyintrinsically disordered proteinsmacromolecular crowdingnanomaterialspartially folded intermediate |
| spellingShingle | Munishwar Nath Gupta Vladimir N. Uversky Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins International Journal of Molecular Sciences baroenzymology cryoenzymology intrinsically disordered proteins macromolecular crowding nanomaterials partially folded intermediate |
| title | Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins |
| title_full | Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins |
| title_fullStr | Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins |
| title_full_unstemmed | Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins |
| title_short | Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins |
| title_sort | pre molten wet and dry molten globules en route to the functional state of proteins |
| topic | baroenzymology cryoenzymology intrinsically disordered proteins macromolecular crowding nanomaterials partially folded intermediate |
| url | https://www.mdpi.com/1422-0067/24/3/2424 |
| work_keys_str_mv | AT munishwarnathgupta premoltenwetanddrymoltenglobulesenroutetothefunctionalstateofproteins AT vladimirnuversky premoltenwetanddrymoltenglobulesenroutetothefunctionalstateofproteins |