Human experimental pain models: A review of standardized methods in drug development
Human experimental pain models are essential in understanding the pain mechanisms and appear to be ideally suited to test analgesic compounds. The challenge that confronts both the clinician and the scientist is to match specific treatments to different pain-generating mechanisms and hence reach a p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=6;spage=587;epage=595;aulast=Reddy |
| _version_ | 1819276933047779328 |
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| author | K. Sunil kumar Reddy M. U. R Naidu Usha P Rani T. Ramesh Kumar Rao |
| author_facet | K. Sunil kumar Reddy M. U. R Naidu Usha P Rani T. Ramesh Kumar Rao |
| author_sort | K. Sunil kumar Reddy |
| collection | DOAJ |
| description | Human experimental pain models are essential in understanding the pain mechanisms and appear to be ideally suited to test analgesic compounds. The challenge that confronts both the clinician and the scientist is to match specific treatments to different pain-generating mechanisms and hence reach a pain treatment tailored to each individual patient. Experimental pain models offer the possibility to explore the pain system under controlled settings. Standardized stimuli of different modalities (i.e., mechanical, thermal, electrical, or chemical) can be applied to the skin, muscles, and viscera for a differentiated and comprehensive assessment of various pain pathways and mechanisms. Using a multimodel-multistructure testing, the nociception arising from different body structures can be explored and modulation of specific biomarkers by new and existing analgesic drugs can be profiled. The value of human experimental pain models is to link animal and clinical pain studies, providing new possibilities for designing successful clinical trials. Spontaneous pain, the main compliant of the neuropathic patients, but currently there is no human model available that would mimic chronic pain. Therefore, current human pain models cannot replace patient studies for studying efficacy of analgesic compounds, although being helpful for proof-of-concept studies and dose finding. |
| first_indexed | 2024-12-23T23:48:05Z |
| format | Article |
| id | doaj.art-3ccc36d11972495ea6bb414f7ded3b5c |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-23T23:48:05Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-3ccc36d11972495ea6bb414f7ded3b5c2022-12-21T17:25:27ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362012-01-01176587595Human experimental pain models: A review of standardized methods in drug developmentK. Sunil kumar ReddyM. U. R NaiduUsha P RaniT. Ramesh Kumar RaoHuman experimental pain models are essential in understanding the pain mechanisms and appear to be ideally suited to test analgesic compounds. The challenge that confronts both the clinician and the scientist is to match specific treatments to different pain-generating mechanisms and hence reach a pain treatment tailored to each individual patient. Experimental pain models offer the possibility to explore the pain system under controlled settings. Standardized stimuli of different modalities (i.e., mechanical, thermal, electrical, or chemical) can be applied to the skin, muscles, and viscera for a differentiated and comprehensive assessment of various pain pathways and mechanisms. Using a multimodel-multistructure testing, the nociception arising from different body structures can be explored and modulation of specific biomarkers by new and existing analgesic drugs can be profiled. The value of human experimental pain models is to link animal and clinical pain studies, providing new possibilities for designing successful clinical trials. Spontaneous pain, the main compliant of the neuropathic patients, but currently there is no human model available that would mimic chronic pain. Therefore, current human pain models cannot replace patient studies for studying efficacy of analgesic compounds, although being helpful for proof-of-concept studies and dose finding.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=6;spage=587;epage=595;aulast=ReddyAnalgesicsmultimodel-multitissuepain modelsproof-of-conceptspontaneous pain |
| spellingShingle | K. Sunil kumar Reddy M. U. R Naidu Usha P Rani T. Ramesh Kumar Rao Human experimental pain models: A review of standardized methods in drug development Journal of Research in Medical Sciences Analgesics multimodel-multitissue pain models proof-of-concept spontaneous pain |
| title | Human experimental pain models: A review of standardized methods in drug development |
| title_full | Human experimental pain models: A review of standardized methods in drug development |
| title_fullStr | Human experimental pain models: A review of standardized methods in drug development |
| title_full_unstemmed | Human experimental pain models: A review of standardized methods in drug development |
| title_short | Human experimental pain models: A review of standardized methods in drug development |
| title_sort | human experimental pain models a review of standardized methods in drug development |
| topic | Analgesics multimodel-multitissue pain models proof-of-concept spontaneous pain |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=6;spage=587;epage=595;aulast=Reddy |
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