Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer
As a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies which can be broadly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mecha...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2016-10-01
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| Series: | Genomics, Proteomics & Bioinformatics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672022916301000 |
| _version_ | 1827160398049050624 |
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| author | Ming-Ming Wei Guang-Biao Zhou |
| author_facet | Ming-Ming Wei Guang-Biao Zhou |
| author_sort | Ming-Ming Wei |
| collection | DOAJ |
| description | As a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies which can be broadly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mechanisms underlying lung tumorigenesis remain to be elucidated. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs that consist of ⩾200 nucleotides but possess low or no protein-coding potential. Accumulating evidence indicates that abnormal expression of lncRNAs is associated with tumorigenesis of various cancers, including lung cancer, through multiple biological mechanisms involving epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and roles of lncRNAs in NSCLC and discuss their potential clinical applications as diagnostic or prognostic biomarkers, as well as therapeutic targets. |
| first_indexed | 2024-03-08T07:12:26Z |
| format | Article |
| id | doaj.art-3ccdc32753a54b5ca486cbafb098cf41 |
| institution | Directory Open Access Journal |
| issn | 1672-0229 |
| language | English |
| last_indexed | 2025-03-21T00:12:23Z |
| publishDate | 2016-10-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Genomics, Proteomics & Bioinformatics |
| spelling | doaj.art-3ccdc32753a54b5ca486cbafb098cf412024-08-03T09:48:00ZengOxford University PressGenomics, Proteomics & Bioinformatics1672-02292016-10-0114528028810.1016/j.gpb.2016.03.007Long Non-coding RNAs and Their Roles in Non-small-cell Lung CancerMing-Ming Wei0Guang-Biao Zhou1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaAs a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies which can be broadly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mechanisms underlying lung tumorigenesis remain to be elucidated. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs that consist of ⩾200 nucleotides but possess low or no protein-coding potential. Accumulating evidence indicates that abnormal expression of lncRNAs is associated with tumorigenesis of various cancers, including lung cancer, through multiple biological mechanisms involving epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and roles of lncRNAs in NSCLC and discuss their potential clinical applications as diagnostic or prognostic biomarkers, as well as therapeutic targets.http://www.sciencedirect.com/science/article/pii/S1672022916301000Long non-coding RNANon-small-cell lung cancerExpression spectrumBiomarkerTherapeutic resistance |
| spellingShingle | Ming-Ming Wei Guang-Biao Zhou Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer Genomics, Proteomics & Bioinformatics Long non-coding RNA Non-small-cell lung cancer Expression spectrum Biomarker Therapeutic resistance |
| title | Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer |
| title_full | Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer |
| title_fullStr | Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer |
| title_full_unstemmed | Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer |
| title_short | Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer |
| title_sort | long non coding rnas and their roles in non small cell lung cancer |
| topic | Long non-coding RNA Non-small-cell lung cancer Expression spectrum Biomarker Therapeutic resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1672022916301000 |
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