Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19
Abstract Background The role of leukocytes and systemic inflammation indicators in predicting the severity and mortality of inflammatory diseases has been well reported, such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), neutroph...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02397-5 |
| _version_ | 1797854040947687424 |
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| author | Saeed Hosseninia Hassan Ghobadi Kara Garjani Seyed Amir Hossein Hosseini Mohammad Reza Aslani |
| author_facet | Saeed Hosseninia Hassan Ghobadi Kara Garjani Seyed Amir Hossein Hosseini Mohammad Reza Aslani |
| author_sort | Saeed Hosseninia |
| collection | DOAJ |
| description | Abstract Background The role of leukocytes and systemic inflammation indicators in predicting the severity and mortality of inflammatory diseases has been well reported, such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), neutrophil/lymphocyte*platelet ratio (NLPR), derived neutrophil/lymphocyte ratio (dNLR), aggregate index of systemic inflammation (AISI), as well as systemic inflammation response index (SIRI) and systemic inflammation index (SII). The purpose of the present study was to investigate the prognostic role of systemic inflammatory indicators in the mortality of chronic obstructive pulmonary disease (COPD) patients with COVID-19. Methods This retrospective study included 169 COPD patients hospitalized with COVID-19. Demographic, clinical, and laboratory data were obtained from the patients’ electronic records. The ability of systemic inflammation indeces to distinguish the severity of COVID-19 was determined by receiver operating characteristic (ROC) analysis, and survival probability was determined by the mean of Kaplan–Meier curves, with the endpoint being death. Results ROC curves showed that the AUD level was significant for WBC, MLR, SIRI, and AISI. Interestingly, Kaplan-Meier survival curves revealed that survival was lower with higher MLR (HR = 2.022, 95% CI = 1.030 to 3.968, P < 0.05) and AISI (HR = 2.010, 95% CI = 1.048 to 3.855, P < 0.05) values. However, the multivariate Cox regression model showed that only AISI was significantly associated with survival. Conclusion AISI in COPD patients with COVID-19 was a reliable predictor of mortality. |
| first_indexed | 2024-04-09T20:00:39Z |
| format | Article |
| id | doaj.art-3ccf5be9edee4c54b3f5b42383efc0b4 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-09T20:00:39Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-3ccf5be9edee4c54b3f5b42383efc0b42023-04-03T05:15:11ZengBMCBMC Pulmonary Medicine1471-24662023-03-012311910.1186/s12890-023-02397-5Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19Saeed Hosseninia0Hassan Ghobadi1Kara Garjani2Seyed Amir Hossein Hosseini3Mohammad Reza Aslani4Lung Diseases Research Center, Ardabil University of Medical SciencesLung Diseases Research Center, Ardabil University of Medical SciencesFaculty of Medicine, Ardabil University of Medical SciencesFaculty of Medicine, Ardabil University of Medical SciencesLung Diseases Research Center, Ardabil University of Medical SciencesAbstract Background The role of leukocytes and systemic inflammation indicators in predicting the severity and mortality of inflammatory diseases has been well reported, such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), neutrophil/lymphocyte*platelet ratio (NLPR), derived neutrophil/lymphocyte ratio (dNLR), aggregate index of systemic inflammation (AISI), as well as systemic inflammation response index (SIRI) and systemic inflammation index (SII). The purpose of the present study was to investigate the prognostic role of systemic inflammatory indicators in the mortality of chronic obstructive pulmonary disease (COPD) patients with COVID-19. Methods This retrospective study included 169 COPD patients hospitalized with COVID-19. Demographic, clinical, and laboratory data were obtained from the patients’ electronic records. The ability of systemic inflammation indeces to distinguish the severity of COVID-19 was determined by receiver operating characteristic (ROC) analysis, and survival probability was determined by the mean of Kaplan–Meier curves, with the endpoint being death. Results ROC curves showed that the AUD level was significant for WBC, MLR, SIRI, and AISI. Interestingly, Kaplan-Meier survival curves revealed that survival was lower with higher MLR (HR = 2.022, 95% CI = 1.030 to 3.968, P < 0.05) and AISI (HR = 2.010, 95% CI = 1.048 to 3.855, P < 0.05) values. However, the multivariate Cox regression model showed that only AISI was significantly associated with survival. Conclusion AISI in COPD patients with COVID-19 was a reliable predictor of mortality.https://doi.org/10.1186/s12890-023-02397-5CoronavirusCOVID-19COPDAggregate index of systemic inflammation |
| spellingShingle | Saeed Hosseninia Hassan Ghobadi Kara Garjani Seyed Amir Hossein Hosseini Mohammad Reza Aslani Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 BMC Pulmonary Medicine Coronavirus COVID-19 COPD Aggregate index of systemic inflammation |
| title | Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 |
| title_full | Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 |
| title_fullStr | Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 |
| title_full_unstemmed | Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 |
| title_short | Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19 |
| title_sort | aggregate index of systemic inflammation aisi in admission as a reliable predictor of mortality in copd patients with covid 19 |
| topic | Coronavirus COVID-19 COPD Aggregate index of systemic inflammation |
| url | https://doi.org/10.1186/s12890-023-02397-5 |
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