Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection
With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/4/85 |
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| author | Anton Popov Benediktas Brasiunas Asta Kausaite-Minkstimiene Almira Ramanaviciene |
| author_facet | Anton Popov Benediktas Brasiunas Asta Kausaite-Minkstimiene Almira Ramanaviciene |
| author_sort | Anton Popov |
| collection | DOAJ |
| description | With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed. |
| first_indexed | 2024-03-10T12:12:22Z |
| format | Article |
| id | doaj.art-3cd0f49d9b9042a3a24809f179d7bffb |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T12:12:22Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-3cd0f49d9b9042a3a24809f179d7bffb2023-11-21T16:05:44ZengMDPI AGChemosensors2227-90402021-04-01948510.3390/chemosensors9040085Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker DetectionAnton Popov0Benediktas Brasiunas1Asta Kausaite-Minkstimiene2Almira Ramanaviciene3Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaNanoTechnas—Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Institute of Chemistry, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, LithuaniaDepartment of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaWith the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.https://www.mdpi.com/2227-9040/9/4/85metal nanoparticlesgold nanoparticlesquantum dotselectrochemical signal amplifying tagsantibody immobilizationbiomarkers |
| spellingShingle | Anton Popov Benediktas Brasiunas Asta Kausaite-Minkstimiene Almira Ramanaviciene Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection Chemosensors metal nanoparticles gold nanoparticles quantum dots electrochemical signal amplifying tags antibody immobilization biomarkers |
| title | Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection |
| title_full | Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection |
| title_fullStr | Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection |
| title_full_unstemmed | Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection |
| title_short | Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection |
| title_sort | metal nanoparticle and quantum dot tags for signal amplification in electrochemical immunosensors for biomarker detection |
| topic | metal nanoparticles gold nanoparticles quantum dots electrochemical signal amplifying tags antibody immobilization biomarkers |
| url | https://www.mdpi.com/2227-9040/9/4/85 |
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